A comparison of structural connectivity in anxious depression versus non-anxious depression

Lauren Delaparte, Fang Cheng Yeh, Phil Adams, Ashley Malchow, Madhukar H. Trivedi, Maria A. Oquendo, Thilo Deckersbach, Todd Ogden, Diego A. Pizzagalli, Maurizio Fava, Crystal Cooper, Melvin McInnis, Benji T. Kurian, Myrna M. Weissman, Patrick J. McGrath, Daniel N. Klein, Ramin V. Parsey, Christine DeLorenzo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals. Methods 64- direction DTI and T1 scans were collected from 110 unmedicated subjects with MDD, 39 of whom had a co-morbid anxiety disorder diagnosis. Region of interest (ROI) and tractography methods were performed to calculate amygdala volume and FA in the uncinate fasciculus, respectively. Diffusion connectometry was performed to identify whole brain group differences in white matter health. Correlations were computed between biological and clinical measures. Results Tractography and ROI analyses showed no significant differences between bilateral FA values or bilateral amygdala volumes when comparing the anxious depressed and non-anxious depressed groups. The diffusion connectometry analysis showed no significant differences in anisotropy between the groups. Furthermore, there were no significant relationships between MRI-based and clinical measures. Conclusion The lack of group differences could indicate that structural connectivity and amygdalae volumes of those with anxious-depression are not significantly altered by a co-morbid anxiety disorder. Improving understanding of anxiety co-morbid with MDD would facilitate development of treatments that more accurately target the underlying networks.

Original languageEnglish (US)
Pages (from-to)38-47
Number of pages10
JournalJournal of Psychiatric Research
Volume89
DOIs
StatePublished - Jun 1 2017

Fingerprint

Amygdala
Anisotropy
Anxiety Disorders
Depression
Major Depressive Disorder
Mood Disorders
Anxiety
Connectivity
Health
Brain
Research
White Matter
Group Differences

Keywords

  • Anxiety
  • Anxious-depression
  • Depression
  • Diffusion tensor imaging
  • Fractional anisotropy
  • White matter health

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

A comparison of structural connectivity in anxious depression versus non-anxious depression. / Delaparte, Lauren; Yeh, Fang Cheng; Adams, Phil; Malchow, Ashley; Trivedi, Madhukar H.; Oquendo, Maria A.; Deckersbach, Thilo; Ogden, Todd; Pizzagalli, Diego A.; Fava, Maurizio; Cooper, Crystal; McInnis, Melvin; Kurian, Benji T.; Weissman, Myrna M.; McGrath, Patrick J.; Klein, Daniel N.; Parsey, Ramin V.; DeLorenzo, Christine.

In: Journal of Psychiatric Research, Vol. 89, 01.06.2017, p. 38-47.

Research output: Contribution to journalArticle

Delaparte, L, Yeh, FC, Adams, P, Malchow, A, Trivedi, MH, Oquendo, MA, Deckersbach, T, Ogden, T, Pizzagalli, DA, Fava, M, Cooper, C, McInnis, M, Kurian, BT, Weissman, MM, McGrath, PJ, Klein, DN, Parsey, RV & DeLorenzo, C 2017, 'A comparison of structural connectivity in anxious depression versus non-anxious depression', Journal of Psychiatric Research, vol. 89, pp. 38-47. https://doi.org/10.1016/j.jpsychires.2017.01.012
Delaparte, Lauren ; Yeh, Fang Cheng ; Adams, Phil ; Malchow, Ashley ; Trivedi, Madhukar H. ; Oquendo, Maria A. ; Deckersbach, Thilo ; Ogden, Todd ; Pizzagalli, Diego A. ; Fava, Maurizio ; Cooper, Crystal ; McInnis, Melvin ; Kurian, Benji T. ; Weissman, Myrna M. ; McGrath, Patrick J. ; Klein, Daniel N. ; Parsey, Ramin V. ; DeLorenzo, Christine. / A comparison of structural connectivity in anxious depression versus non-anxious depression. In: Journal of Psychiatric Research. 2017 ; Vol. 89. pp. 38-47.
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abstract = "Background Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals. Methods 64- direction DTI and T1 scans were collected from 110 unmedicated subjects with MDD, 39 of whom had a co-morbid anxiety disorder diagnosis. Region of interest (ROI) and tractography methods were performed to calculate amygdala volume and FA in the uncinate fasciculus, respectively. Diffusion connectometry was performed to identify whole brain group differences in white matter health. Correlations were computed between biological and clinical measures. Results Tractography and ROI analyses showed no significant differences between bilateral FA values or bilateral amygdala volumes when comparing the anxious depressed and non-anxious depressed groups. The diffusion connectometry analysis showed no significant differences in anisotropy between the groups. Furthermore, there were no significant relationships between MRI-based and clinical measures. Conclusion The lack of group differences could indicate that structural connectivity and amygdalae volumes of those with anxious-depression are not significantly altered by a co-morbid anxiety disorder. Improving understanding of anxiety co-morbid with MDD would facilitate development of treatments that more accurately target the underlying networks.",
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T1 - A comparison of structural connectivity in anxious depression versus non-anxious depression

AU - Delaparte, Lauren

AU - Yeh, Fang Cheng

AU - Adams, Phil

AU - Malchow, Ashley

AU - Trivedi, Madhukar H.

AU - Oquendo, Maria A.

AU - Deckersbach, Thilo

AU - Ogden, Todd

AU - Pizzagalli, Diego A.

AU - Fava, Maurizio

AU - Cooper, Crystal

AU - McInnis, Melvin

AU - Kurian, Benji T.

AU - Weissman, Myrna M.

AU - McGrath, Patrick J.

AU - Klein, Daniel N.

AU - Parsey, Ramin V.

AU - DeLorenzo, Christine

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals. Methods 64- direction DTI and T1 scans were collected from 110 unmedicated subjects with MDD, 39 of whom had a co-morbid anxiety disorder diagnosis. Region of interest (ROI) and tractography methods were performed to calculate amygdala volume and FA in the uncinate fasciculus, respectively. Diffusion connectometry was performed to identify whole brain group differences in white matter health. Correlations were computed between biological and clinical measures. Results Tractography and ROI analyses showed no significant differences between bilateral FA values or bilateral amygdala volumes when comparing the anxious depressed and non-anxious depressed groups. The diffusion connectometry analysis showed no significant differences in anisotropy between the groups. Furthermore, there were no significant relationships between MRI-based and clinical measures. Conclusion The lack of group differences could indicate that structural connectivity and amygdalae volumes of those with anxious-depression are not significantly altered by a co-morbid anxiety disorder. Improving understanding of anxiety co-morbid with MDD would facilitate development of treatments that more accurately target the underlying networks.

AB - Background Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals. Methods 64- direction DTI and T1 scans were collected from 110 unmedicated subjects with MDD, 39 of whom had a co-morbid anxiety disorder diagnosis. Region of interest (ROI) and tractography methods were performed to calculate amygdala volume and FA in the uncinate fasciculus, respectively. Diffusion connectometry was performed to identify whole brain group differences in white matter health. Correlations were computed between biological and clinical measures. Results Tractography and ROI analyses showed no significant differences between bilateral FA values or bilateral amygdala volumes when comparing the anxious depressed and non-anxious depressed groups. The diffusion connectometry analysis showed no significant differences in anisotropy between the groups. Furthermore, there were no significant relationships between MRI-based and clinical measures. Conclusion The lack of group differences could indicate that structural connectivity and amygdalae volumes of those with anxious-depression are not significantly altered by a co-morbid anxiety disorder. Improving understanding of anxiety co-morbid with MDD would facilitate development of treatments that more accurately target the underlying networks.

KW - Anxiety

KW - Anxious-depression

KW - Depression

KW - Diffusion tensor imaging

KW - Fractional anisotropy

KW - White matter health

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