TY - JOUR
T1 - A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls
AU - Taiym, S.
AU - Haghighat, N.
AU - Al-Hashimi, I.
N1 - Funding Information:
The study was funded in part by NIDCR grant T35-DE07188-11.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/5
Y1 - 2004/5
N2 - Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.
AB - Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.
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U2 - 10.1016/j.tripleo.2003.10.033
DO - 10.1016/j.tripleo.2003.10.033
M3 - Article
C2 - 15153869
AN - SCOPUS:2442426169
SN - 1079-2104
VL - 97
SP - 579
EP - 583
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
IS - 5
ER -