A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls

S. Taiym, N. Haghighat, I. Al-Hashimi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.

Original languageEnglish (US)
Pages (from-to)579-583
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume97
Issue number5
DOIs
StatePublished - May 1 2004

Fingerprint

Sjogren's Syndrome
Progesterone
Prolactin
Hormones
Estrogens
Hormone Replacement Therapy
Nonparametric Statistics
Enzyme-Linked Immunosorbent Assay
Serum

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls. / Taiym, S.; Haghighat, N.; Al-Hashimi, I.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 97, No. 5, 01.05.2004, p. 579-583.

Research output: Contribution to journalArticle

@article{eb8c714f987d47f1b784c8e8f48a4e96,
title = "A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls",
abstract = "Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sj{\"o}gren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sj{\"o}gren's syndrome.",
author = "S. Taiym and N. Haghighat and I. Al-Hashimi",
year = "2004",
month = "5",
day = "1",
doi = "10.1016/j.tripleo.2003.10.033",
language = "English (US)",
volume = "97",
pages = "579--583",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls

AU - Taiym, S.

AU - Haghighat, N.

AU - Al-Hashimi, I.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.

AB - Objective The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls. Study design Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA. Results Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls. Conclusion Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.

UR - http://www.scopus.com/inward/record.url?scp=2442426169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442426169&partnerID=8YFLogxK

U2 - 10.1016/j.tripleo.2003.10.033

DO - 10.1016/j.tripleo.2003.10.033

M3 - Article

C2 - 15153869

AN - SCOPUS:2442426169

VL - 97

SP - 579

EP - 583

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 5

ER -