A Comparison of Three Commercial Perfluorocarbon Emulsions as High-Field 19F NMR Probes of Oxygen Tension and Temperature

H. P. Shukla, R. P. Mason, D. E. Woessner, P. P. Antich

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Abstract

The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the 19F spin-lattice relaxation rate (R1) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R1 with pO2 was confirmed for each resonance in the range 4-50°C, In general, R1 is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R1 values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue pO2 in perfused rat hearts was compared before, during, and after eight minutes of global ischemia.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalJournal of Magnetic Resonance, Series B
Volume106
Issue number2
DOIs
Publication statusPublished - Feb 1995

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ASJC Scopus subject areas

  • Engineering(all)

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