TY - JOUR
T1 - A Comparison of Three Commercial Perfluorocarbon Emulsions as High-Field 19F NMR Probes of Oxygen Tension and Temperature
AU - Shukla, H. P.
AU - Mason, R. P.
AU - Woessner, D. E.
AU - Antich, P. P.
PY - 1995/2
Y1 - 1995/2
N2 - The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the 19F spin-lattice relaxation rate (R1) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R1 with pO2 was confirmed for each resonance in the range 4-50°C, In general, R1 is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R1 values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue pO2 in perfused rat hearts was compared before, during, and after eight minutes of global ischemia.
AB - The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the 19F spin-lattice relaxation rate (R1) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R1 with pO2 was confirmed for each resonance in the range 4-50°C, In general, R1 is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R1 values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue pO2 in perfused rat hearts was compared before, during, and after eight minutes of global ischemia.
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U2 - 10.1006/jmrb.1995.1023
DO - 10.1006/jmrb.1995.1023
M3 - Article
AN - SCOPUS:0000497483
SN - 1064-1866
VL - 106
SP - 131
EP - 141
JO - Journal of Magnetic Resonance, Series B
JF - Journal of Magnetic Resonance, Series B
IS - 2
ER -