A complex relationship

The interaction among symbiotic microbes, invading pathogens, and their mammalian host

M. M. Curtis, V. Sperandio

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Symbiosis between microbes and their mammalian host is vital to maintaining homeostasis. Symbiotic microbes within the gastrointestinal tract provide an array of benefits to the host, including promotion of host immunity. A coordinated effort of the host and symbiotic microbes deters the colonization and survival of many invading pathogens. However, pathogens have devised strategies to overcome these mechanisms. Furthermore, some pathogens can hijack host hormones and bacterial autoinducers to induce virulence traits. Intra- and inter-species (bacteria/bacteria) and interkingdom (bacteria/host) communication orchestrates the complex relationship among symbiotic microbes, invading pathogens, and their mammalian host. Insight into this communication will provide a foundation for the development of targeted antimicrobial therapies.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalMucosal Immunology
Volume4
Issue number2
DOIs
StatePublished - Mar 2011

Fingerprint

Bacteria
Symbiosis
Virulence
Gastrointestinal Tract
Immunity
Homeostasis
Communication
Hormones
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

A complex relationship : The interaction among symbiotic microbes, invading pathogens, and their mammalian host. / Curtis, M. M.; Sperandio, V.

In: Mucosal Immunology, Vol. 4, No. 2, 03.2011, p. 133-138.

Research output: Contribution to journalArticle

@article{98bf27e9f3f34b2b93bd33d188bb9098,
title = "A complex relationship: The interaction among symbiotic microbes, invading pathogens, and their mammalian host",
abstract = "Symbiosis between microbes and their mammalian host is vital to maintaining homeostasis. Symbiotic microbes within the gastrointestinal tract provide an array of benefits to the host, including promotion of host immunity. A coordinated effort of the host and symbiotic microbes deters the colonization and survival of many invading pathogens. However, pathogens have devised strategies to overcome these mechanisms. Furthermore, some pathogens can hijack host hormones and bacterial autoinducers to induce virulence traits. Intra- and inter-species (bacteria/bacteria) and interkingdom (bacteria/host) communication orchestrates the complex relationship among symbiotic microbes, invading pathogens, and their mammalian host. Insight into this communication will provide a foundation for the development of targeted antimicrobial therapies.",
author = "Curtis, {M. M.} and V. Sperandio",
year = "2011",
month = "3",
doi = "10.1038/mi.2010.89",
language = "English (US)",
volume = "4",
pages = "133--138",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - A complex relationship

T2 - The interaction among symbiotic microbes, invading pathogens, and their mammalian host

AU - Curtis, M. M.

AU - Sperandio, V.

PY - 2011/3

Y1 - 2011/3

N2 - Symbiosis between microbes and their mammalian host is vital to maintaining homeostasis. Symbiotic microbes within the gastrointestinal tract provide an array of benefits to the host, including promotion of host immunity. A coordinated effort of the host and symbiotic microbes deters the colonization and survival of many invading pathogens. However, pathogens have devised strategies to overcome these mechanisms. Furthermore, some pathogens can hijack host hormones and bacterial autoinducers to induce virulence traits. Intra- and inter-species (bacteria/bacteria) and interkingdom (bacteria/host) communication orchestrates the complex relationship among symbiotic microbes, invading pathogens, and their mammalian host. Insight into this communication will provide a foundation for the development of targeted antimicrobial therapies.

AB - Symbiosis between microbes and their mammalian host is vital to maintaining homeostasis. Symbiotic microbes within the gastrointestinal tract provide an array of benefits to the host, including promotion of host immunity. A coordinated effort of the host and symbiotic microbes deters the colonization and survival of many invading pathogens. However, pathogens have devised strategies to overcome these mechanisms. Furthermore, some pathogens can hijack host hormones and bacterial autoinducers to induce virulence traits. Intra- and inter-species (bacteria/bacteria) and interkingdom (bacteria/host) communication orchestrates the complex relationship among symbiotic microbes, invading pathogens, and their mammalian host. Insight into this communication will provide a foundation for the development of targeted antimicrobial therapies.

UR - http://www.scopus.com/inward/record.url?scp=79951868491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951868491&partnerID=8YFLogxK

U2 - 10.1038/mi.2010.89

DO - 10.1038/mi.2010.89

M3 - Article

VL - 4

SP - 133

EP - 138

JO - Mucosal Immunology

JF - Mucosal Immunology

SN - 1933-0219

IS - 2

ER -