Abstract
This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes.
Original language | English (US) |
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Pages (from-to) | 468-469 |
Number of pages | 2 |
Journal | DNA repair |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - Apr 4 2010 |
Keywords
- Cancer genomes
- Somatic mutations
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology