A comprehensive classification system for lipids

Eoin Fahy, Shankar Subramaniam, H. Alex Brown, Christopher K. Glass, Alfred H. Merrill, Robert C. Murphy, Christian R H Raetz, David W. Russell, Yousuke Seyama, Walter Shaw, Takao Shimizu, Friedrich Spener, Gerrit Van Meer, Michael S. VanNieuwenhze, Stephen H. White, Joseph L. Witztum, Edward A. Dennis

Research output: Contribution to journalArticle

765 Citations (Scopus)

Abstract

Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, "lipidomics," in the context of genomics and proteomics is crucial to understanding cellular physiology and pathology; consequently, lipid biology has become a major research target of the postgenomic revolution and systems biology. To facilitate international communication about lipids, a comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by our lipid community. As an initial step in this development, we divide lipids into eight categories (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, prenol lipids, saccharolipids, and polyketides) containing distinct classes and subclasses of molecules, devise a common manner of representing the chemical structures of individual lipids and their derivatives, and provide a 12 digit identifier for each unique lipid molecule. The lipid classification scheme is chemically based and driven by the distinct hydrophobic and hydrophilic elements that compose the lipid. This structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.

Original languageEnglish (US)
Pages (from-to)839-861
Number of pages23
JournalJournal of Lipid Research
Volume46
Issue number5
DOIs
StatePublished - 2005

Fingerprint

Lipids
Molecules
Cataloging
Glycerophospholipids
Polyketides
Sphingolipids
Informatics
Systems Biology
Vocabulary
Physiology
Pathology
Sterols
Genomics
Proteomics
Carrier Proteins
Databases
Derivatives
Communication
Enzymes

Keywords

  • Chemical representation
  • Fatty acyls
  • Glycerolipids
  • Glycerophospholipids
  • Informatics
  • Lipidomics
  • Nomenclature
  • Polyketides
  • Prenol lipids
  • Saccharolipids
  • Sphingolipids
  • Sterol lipids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Fahy, E., Subramaniam, S., Brown, H. A., Glass, C. K., Merrill, A. H., Murphy, R. C., ... Dennis, E. A. (2005). A comprehensive classification system for lipids. Journal of Lipid Research, 46(5), 839-861. https://doi.org/10.1194/jlr.E400004-JLR200

A comprehensive classification system for lipids. / Fahy, Eoin; Subramaniam, Shankar; Brown, H. Alex; Glass, Christopher K.; Merrill, Alfred H.; Murphy, Robert C.; Raetz, Christian R H; Russell, David W.; Seyama, Yousuke; Shaw, Walter; Shimizu, Takao; Spener, Friedrich; Van Meer, Gerrit; VanNieuwenhze, Michael S.; White, Stephen H.; Witztum, Joseph L.; Dennis, Edward A.

In: Journal of Lipid Research, Vol. 46, No. 5, 2005, p. 839-861.

Research output: Contribution to journalArticle

Fahy, E, Subramaniam, S, Brown, HA, Glass, CK, Merrill, AH, Murphy, RC, Raetz, CRH, Russell, DW, Seyama, Y, Shaw, W, Shimizu, T, Spener, F, Van Meer, G, VanNieuwenhze, MS, White, SH, Witztum, JL & Dennis, EA 2005, 'A comprehensive classification system for lipids', Journal of Lipid Research, vol. 46, no. 5, pp. 839-861. https://doi.org/10.1194/jlr.E400004-JLR200
Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC et al. A comprehensive classification system for lipids. Journal of Lipid Research. 2005;46(5):839-861. https://doi.org/10.1194/jlr.E400004-JLR200
Fahy, Eoin ; Subramaniam, Shankar ; Brown, H. Alex ; Glass, Christopher K. ; Merrill, Alfred H. ; Murphy, Robert C. ; Raetz, Christian R H ; Russell, David W. ; Seyama, Yousuke ; Shaw, Walter ; Shimizu, Takao ; Spener, Friedrich ; Van Meer, Gerrit ; VanNieuwenhze, Michael S. ; White, Stephen H. ; Witztum, Joseph L. ; Dennis, Edward A. / A comprehensive classification system for lipids. In: Journal of Lipid Research. 2005 ; Vol. 46, No. 5. pp. 839-861.
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