A comprehensive review of topical hemostatic agents: The good, the bad, and the novel

Allison J. Tompeck, Aniq Ur Reham Gajdhar, Matthew Dowling, Steven B. Johnson, Philip S. Barie, Robert J. Winchell, David King, Thomas M. Scalea, L. D. Britt, Mayur Narayan

Research output: Contribution to journalReview article

Abstract

Uncontrolled exsanguination remains the leading cause of death for trauma patients, many of whom die in the pre-hospital setting. Without expedient intervention, trauma-associated hemorrhage induces a host of systemic responses and acute coagulopathy of trauma. For this reason, health care providers and prehospital personal face the challenge of swift and effective hemorrhage control. The utilization of adjuncts to facilitate hemostasis was first recorded in 1886. Commercially available products haves since expanded to include topical hemostats, surgical sealants, and adhesives. The ideal product balances efficacy, with safety practicality and cost-effectiveness. This review of hemostasis provides a guide for successful implementation and simultaneously highlights future opportunities.

Original languageEnglish (US)
Pages (from-to)E1-E21
JournalJournal of Trauma and Acute Care Surgery
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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    Tompeck, A. J., Gajdhar, A. U. R., Dowling, M., Johnson, S. B., Barie, P. S., Winchell, R. J., King, D., Scalea, T. M., Britt, L. D., & Narayan, M. (2020). A comprehensive review of topical hemostatic agents: The good, the bad, and the novel. Journal of Trauma and Acute Care Surgery, 88(1), E1-E21. https://doi.org/10.1097/TA.0000000000002508