A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs

Y. Megan Kong, Raymond J. MacDonald, Xiaofei Wen, Peng Yang, Victor M. Barbera, Galvin H. Swift

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A global survey of RNA from 14 fetal and 12 adult human organs by RT-PCR determined the expression patterns of 790 genes encoding DNA-binding transcription factors. The data can be sorted to identify sets of transcription factors with expression relatively restricted to a given organ or to particular organ groups. These data are a resource to help define the spectrum of transcription factor control, contribute to the elucidation of transcription factor cascades responsible for the development and maintenance of each organ, and provide a baseline to study the effects of disease or developmental defects.

Original languageEnglish (US)
Pages (from-to)678-686
Number of pages9
JournalGene Expression Patterns
Volume6
Issue number7
DOIs
StatePublished - Oct 1 2006

Keywords

  • Expression survey
  • RT-PCR
  • Transcription factor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology

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