A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)- tetraenoic acid, an endogenous vasoconstrictor

S. G. Jagadeesh, L. Manmohan Reddy, Alberto Nasjletti, J R Falck

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries.

Original languageEnglish (US)
Pages (from-to)7111-7113
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number38
DOIs
StatePublished - Sep 13 2004

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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