Abstract
(Chemical Equation Presented) We describe a highly convergent synthetic approach to the natural product (+)-SCH 351448 (1) - a hexane-soluble heptacoordinate monosodium salt of a C2-symmetrical macrocyclic dilactone. Our approach implements a photochemical acylation as the key step to combine two nearly identical but orthogonal C1-C29 fragments, followed by a base-induced intramolecular acylation and deprotection to yield the natural product.
Original language | English (US) |
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Pages (from-to) | 2791-2793 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 13 |
DOIs | |
State | Published - 2005 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry