A controlled study of intrathecal antibiotic therapy in gram-negative enteric meningitis of infancy. Report of the Neonatal Meningitis Cooperative Study Group

George H. McCracken, Susan G. Mize

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174 Citations (Scopus)

Abstract

Eighteen institutions collaborated in evaluating the comparative efficacy of combined ampicillin and gentamicin therapy with and without intrathecal administration of gentamicin on the clinical and bacteriologic responses of 117 infants with meningitis caused by gram-negative enteric bacteria. There was a random distribution of patients within the two study groups with regard to age on enrollment, birth weight, sex, race, number of infants greater than 30 days of age, the etiologic agent, and their antimicrobial susceptibilities. There were no statistically significant differences (P>0.05) in mortality, morbidity, or days that cerebrospinal fluid cultures remained positive among the infants in the two treatment groups. The case fatality rate for all patients was 32%; that for full-term infants (18%) was significantly lower (P<0.01) than that for low-birth-weight infants (45%) or for the patients greater than 30 days of age (48%). Fifty-one of the 80 (64%) survivors were assessed as normal on follow-up examinations performed up to four years after illness.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalThe Journal of Pediatrics
Volume89
Issue number1
DOIs
StatePublished - 1976

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Meningitis
Anti-Bacterial Agents
Gentamicins
Mortality
Low Birth Weight Infant
Enterobacteriaceae
Therapeutics
Ampicillin
Anti-Infective Agents
Gram-Negative Bacteria
Birth Weight
Survivors
Cerebrospinal Fluid
Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Eighteen institutions collaborated in evaluating the comparative efficacy of combined ampicillin and gentamicin therapy with and without intrathecal administration of gentamicin on the clinical and bacteriologic responses of 117 infants with meningitis caused by gram-negative enteric bacteria. There was a random distribution of patients within the two study groups with regard to age on enrollment, birth weight, sex, race, number of infants greater than 30 days of age, the etiologic agent, and their antimicrobial susceptibilities. There were no statistically significant differences (P>0.05) in mortality, morbidity, or days that cerebrospinal fluid cultures remained positive among the infants in the two treatment groups. The case fatality rate for all patients was 32{\%}; that for full-term infants (18{\%}) was significantly lower (P<0.01) than that for low-birth-weight infants (45{\%}) or for the patients greater than 30 days of age (48{\%}). Fifty-one of the 80 (64{\%}) survivors were assessed as normal on follow-up examinations performed up to four years after illness.",
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