TY - JOUR
T1 - A controlled study of intrathecal antibiotic therapy in gram-negative enteric meningitis of infancy. Report of the Neonatal Meningitis Cooperative Study Group
AU - McCracken, George H.
AU - Mize, Susan G.
N1 - Funding Information:
*Charles A. A lford (Birmingham), Bernard Boxerbaum (Cleveland), Ernesto Calderon (Mexico City), Moses Grossman (San Francisco), Marc Gurwith (Winnipeg), William Hayden (Madison), Jerome Klein (Boston), Sheldon Korones (Memphis), Irwin Light (Cincinnati), Aarolyn Visintine and Andre Nahmias (Atlanta), James Ove:all (Salt Lake City), Herman Risemberg (Baltimore), Melvin L Marks (Montreal), Richard Michaels (Pittsburgh), Hugo Trujillo (Medellin), Catherine M. Wilfert (Durham), Harry T. Wright (Los Angeles), George McCracken (Coordinator, Dallas), Susan Mize (Statistician, Dallas). This study was supported by a grant from Schering Corporation, Bloomfield, N.J. **Reprint address: Department of Pediatrics, 5323 Harry Hines Blvd, Dallas, Texas 75235.
PY - 1976/7
Y1 - 1976/7
N2 - Eighteen institutions collaborated in evaluating the comparative efficacy of combined ampicillin and gentamicin therapy with and without intrathecal administration of gentamicin on the clinical and bacteriologic responses of 117 infants with meningitis caused by gram-negative enteric bacteria. There was a random distribution of patients within the two study groups with regard to age on enrollment, birth weight, sex, race, number of infants greater than 30 days of age, the etiologic agent, and their antimicrobial susceptibilities. There were no statistically significant differences (P>0.05) in mortality, morbidity, or days that cerebrospinal fluid cultures remained positive among the infants in the two treatment groups. The case fatality rate for all patients was 32%; that for full-term infants (18%) was significantly lower (P<0.01) than that for low-birth-weight infants (45%) or for the patients greater than 30 days of age (48%). Fifty-one of the 80 (64%) survivors were assessed as normal on follow-up examinations performed up to four years after illness.
AB - Eighteen institutions collaborated in evaluating the comparative efficacy of combined ampicillin and gentamicin therapy with and without intrathecal administration of gentamicin on the clinical and bacteriologic responses of 117 infants with meningitis caused by gram-negative enteric bacteria. There was a random distribution of patients within the two study groups with regard to age on enrollment, birth weight, sex, race, number of infants greater than 30 days of age, the etiologic agent, and their antimicrobial susceptibilities. There were no statistically significant differences (P>0.05) in mortality, morbidity, or days that cerebrospinal fluid cultures remained positive among the infants in the two treatment groups. The case fatality rate for all patients was 32%; that for full-term infants (18%) was significantly lower (P<0.01) than that for low-birth-weight infants (45%) or for the patients greater than 30 days of age (48%). Fifty-one of the 80 (64%) survivors were assessed as normal on follow-up examinations performed up to four years after illness.
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U2 - 10.1016/S0022-3476(76)80929-8
DO - 10.1016/S0022-3476(76)80929-8
M3 - Article
C2 - 778366
AN - SCOPUS:0017117977
SN - 0022-3476
VL - 89
SP - 66
EP - 72
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 1
ER -