A controlled study of the antidepressant efficacy and side effects of (-)-deprenyl. A selective monoamine oxidase inhibitor

J. J. Mann, S. F. Aarons, P. J. Wilner, J. G. Keilp, J. A. Sweeney, T. Pearlstein, A. J. Frances, J. H. Kocsis, R. P. Brown

Research output: Contribution to journalArticle

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Abstract

Monoamine oxidase (MAO) inhibitors are effective antidepressants whose use is limited because of unwanted side effects and the possibility of a tyranine-induced hypertensive crisis (cheese reaction). (-)-Deprenyl (the official nonproprietary name for this substance is selegiline), a selective MAO type B inhibitor, may be safer and have fewer side effects, but its antidepressant efficacy is uncertain. A double-blind placebo-controlled study was carried out in depressed outpatients who were treated with (-)-deprenyl in an MAO type B selective dose range and at a higher nonselective dose range. (-)-Deprenyl did not have a statistically significant antidepressant effect after three weeks of treatment at doses of 10 mg/d. However, after six weeks and at higher doses (averaging about 30 mg/d for the second three weeks), (-)-deprenyl was superior to placebo in antidepressant effect with a positive response rate to 50% vs 13.6% and with a 41% reduction in the Hamilton Depression Rating Scale mean score vs 10% in the placebo-treated group. No hypertensive crises were seen. The rate of occurrence of side effects with (-)-deprenyl was no greater than with placebo. It was concluded that (-)-deprenyl is an effective antidepressant in a dose range where it is distinguished by the absence of many of the side effects typical of nonselective MAO inhibitors.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalArchives of General Psychiatry
Volume46
Issue number1
StatePublished - 1989

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Selegiline
Monoamine Oxidase Inhibitors
Antidepressive Agents
Placebos
Monoamine Oxidase
Cheese
Names
Outpatients

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Mann, J. J., Aarons, S. F., Wilner, P. J., Keilp, J. G., Sweeney, J. A., Pearlstein, T., ... Brown, R. P. (1989). A controlled study of the antidepressant efficacy and side effects of (-)-deprenyl. A selective monoamine oxidase inhibitor. Archives of General Psychiatry, 46(1), 45-50.

A controlled study of the antidepressant efficacy and side effects of (-)-deprenyl. A selective monoamine oxidase inhibitor. / Mann, J. J.; Aarons, S. F.; Wilner, P. J.; Keilp, J. G.; Sweeney, J. A.; Pearlstein, T.; Frances, A. J.; Kocsis, J. H.; Brown, R. P.

In: Archives of General Psychiatry, Vol. 46, No. 1, 1989, p. 45-50.

Research output: Contribution to journalArticle

Mann, JJ, Aarons, SF, Wilner, PJ, Keilp, JG, Sweeney, JA, Pearlstein, T, Frances, AJ, Kocsis, JH & Brown, RP 1989, 'A controlled study of the antidepressant efficacy and side effects of (-)-deprenyl. A selective monoamine oxidase inhibitor', Archives of General Psychiatry, vol. 46, no. 1, pp. 45-50.
Mann, J. J. ; Aarons, S. F. ; Wilner, P. J. ; Keilp, J. G. ; Sweeney, J. A. ; Pearlstein, T. ; Frances, A. J. ; Kocsis, J. H. ; Brown, R. P. / A controlled study of the antidepressant efficacy and side effects of (-)-deprenyl. A selective monoamine oxidase inhibitor. In: Archives of General Psychiatry. 1989 ; Vol. 46, No. 1. pp. 45-50.
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