A critical evaluation of the role of phosphate in the pathogenesis of absorptive hypercalciuria

D. E. Barilla, J. E. Zerwekh, C. Y C Pak

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Abstract

The role of serum phosphorus (P) in the pathogenesis of absorptive hypercalciuria was assessed in 56 patients by an examination of serum P, renal phosphate threshold (TmP), and serum 1α,25-dihydroxyvitamin D [1α,25-(OH)2D]. Serum P and TmP were in the lower part of the normal range during outpatient evaluation (P intake 800-1,500 mg/day), but rose significantly during 3 days of hospitalization on a constant P intake (800 mg/day), while serum 1α,25-(OH)2D remained essentially unchanged. There was no correlation between serum P or TmP with serum 1α,25-(OH)2D, intestinal calcium (Ca) absorption, fasting urinary Ca, urinary hydroxyproline, or bone density. Orthophosphate therapy did not significantly change serum P, TmP, or serum 1α,25(OH)2D after 1 month of treatment, but these parameters were significantly decreased by 2-4 months of therapy. Despite the fall in serum 1α,25-(OH)2D concentration, the intestinal absorption of Ca remained elevated. The results do not support a major pathogenetic role for serum P in absorptive hypercalciuria.

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalMineral and Electrolyte Metabolism
Volume2
Issue number6
StatePublished - 1979

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Hypercalciuria
Phosphates
Calcium
Serum
Hydroxyproline
Phosphorus
Bone
Intestinal Absorption
Bone Density
Fasting
Reference Values
Hospitalization
Outpatients
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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A critical evaluation of the role of phosphate in the pathogenesis of absorptive hypercalciuria. / Barilla, D. E.; Zerwekh, J. E.; Pak, C. Y C.

In: Mineral and Electrolyte Metabolism, Vol. 2, No. 6, 1979, p. 302-309.

Research output: Contribution to journalArticle

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abstract = "The role of serum phosphorus (P) in the pathogenesis of absorptive hypercalciuria was assessed in 56 patients by an examination of serum P, renal phosphate threshold (TmP), and serum 1α,25-dihydroxyvitamin D [1α,25-(OH)2D]. Serum P and TmP were in the lower part of the normal range during outpatient evaluation (P intake 800-1,500 mg/day), but rose significantly during 3 days of hospitalization on a constant P intake (800 mg/day), while serum 1α,25-(OH)2D remained essentially unchanged. There was no correlation between serum P or TmP with serum 1α,25-(OH)2D, intestinal calcium (Ca) absorption, fasting urinary Ca, urinary hydroxyproline, or bone density. Orthophosphate therapy did not significantly change serum P, TmP, or serum 1α,25(OH)2D after 1 month of treatment, but these parameters were significantly decreased by 2-4 months of therapy. Despite the fall in serum 1α,25-(OH)2D concentration, the intestinal absorption of Ca remained elevated. The results do not support a major pathogenetic role for serum P in absorptive hypercalciuria.",
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