A critical role for dorsal progenitors in cortical myelination

Tao Yue, Kendy Xian, Edward Hurlock, Mei Xin, Steven G. Kernie, Luis F. Parada, Q. Richard Lu

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

Original languageEnglish (US)
Pages (from-to)1275-1280
Number of pages6
JournalJournal of Neuroscience
Volume26
Issue number4
DOIs
StatePublished - Jan 25 2006

Keywords

  • Cortex
  • Knock-out mice
  • Myelination
  • Olig2
  • Oligodendrocyte
  • bHLH transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

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    Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F., & Lu, Q. R. (2006). A critical role for dorsal progenitors in cortical myelination. Journal of Neuroscience, 26(4), 1275-1280. https://doi.org/10.1523/JNEUROSCI.4717-05.2006