A critical role for dorsal progenitors in cortical myelination

Tao Yue, Kendy Xian, Edward Hurlock, Mei Xin, Steven G. Kernie, Luis F. Parada, Q. Richard Lu

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

Original languageEnglish (US)
Pages (from-to)1275-1280
Number of pages6
JournalJournal of Neuroscience
Volume26
Issue number4
DOIs
StatePublished - Jan 25 2006

Fingerprint

Oligodendroglia
Basic Helix-Loop-Helix Transcription Factors
Telencephalon
Rhombencephalon
Spinal Cord

Keywords

  • bHLH transcription factor
  • Cortex
  • Knock-out mice
  • Myelination
  • Olig2
  • Oligodendrocyte

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F., & Lu, Q. R. (2006). A critical role for dorsal progenitors in cortical myelination. Journal of Neuroscience, 26(4), 1275-1280. https://doi.org/10.1523/JNEUROSCI.4717-05.2006

A critical role for dorsal progenitors in cortical myelination. / Yue, Tao; Xian, Kendy; Hurlock, Edward; Xin, Mei; Kernie, Steven G.; Parada, Luis F.; Lu, Q. Richard.

In: Journal of Neuroscience, Vol. 26, No. 4, 25.01.2006, p. 1275-1280.

Research output: Contribution to journalArticle

Yue, T, Xian, K, Hurlock, E, Xin, M, Kernie, SG, Parada, LF & Lu, QR 2006, 'A critical role for dorsal progenitors in cortical myelination', Journal of Neuroscience, vol. 26, no. 4, pp. 1275-1280. https://doi.org/10.1523/JNEUROSCI.4717-05.2006
Yue, Tao ; Xian, Kendy ; Hurlock, Edward ; Xin, Mei ; Kernie, Steven G. ; Parada, Luis F. ; Lu, Q. Richard. / A critical role for dorsal progenitors in cortical myelination. In: Journal of Neuroscience. 2006 ; Vol. 26, No. 4. pp. 1275-1280.
@article{b35330db46354e399ce4f77dc5dc6209,
title = "A critical role for dorsal progenitors in cortical myelination",
abstract = "Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.",
keywords = "bHLH transcription factor, Cortex, Knock-out mice, Myelination, Olig2, Oligodendrocyte",
author = "Tao Yue and Kendy Xian and Edward Hurlock and Mei Xin and Kernie, {Steven G.} and Parada, {Luis F.} and Lu, {Q. Richard}",
year = "2006",
month = "1",
day = "25",
doi = "10.1523/JNEUROSCI.4717-05.2006",
language = "English (US)",
volume = "26",
pages = "1275--1280",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "4",

}

TY - JOUR

T1 - A critical role for dorsal progenitors in cortical myelination

AU - Yue, Tao

AU - Xian, Kendy

AU - Hurlock, Edward

AU - Xin, Mei

AU - Kernie, Steven G.

AU - Parada, Luis F.

AU - Lu, Q. Richard

PY - 2006/1/25

Y1 - 2006/1/25

N2 - Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

AB - Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

KW - bHLH transcription factor

KW - Cortex

KW - Knock-out mice

KW - Myelination

KW - Olig2

KW - Oligodendrocyte

UR - http://www.scopus.com/inward/record.url?scp=32544461258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32544461258&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.4717-05.2006

DO - 10.1523/JNEUROSCI.4717-05.2006

M3 - Article

C2 - 16436615

AN - SCOPUS:32544461258

VL - 26

SP - 1275

EP - 1280

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 4

ER -