A critical role for dorsal progenitors in cortical myelination

Tao Yue; Kendy Xian; Edward Hurlock; Mei Xin; Steven G. Kernie; Luis F. Parada; Q. Richard Lu

doi:10.1523/JNEUROSCI.4717-05.2006

A critical role for dorsal progenitors in cortical myelination

Tao Yue, Kendy Xian, Edward Hurlock, Mei Xin, Steven G. Kernie, Luis F. Parada, Q. Richard Lu

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

Original language	English (US)
Pages (from-to)	1275-1280
Number of pages	6
Journal	Journal of Neuroscience
Volume	26
Issue number	4
DOIs	https://doi.org/10.1523/JNEUROSCI.4717-05.2006
State	Published - Jan 25 2006

Keywords

Cortex
Knock-out mice
Myelination
Olig2
Oligodendrocyte
bHLH transcription factor

ASJC Scopus subject areas

General Neuroscience

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10.1523/JNEUROSCI.4717-05.2006

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title = "A critical role for dorsal progenitors in cortical myelination",

abstract = "Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.",

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T1 - A critical role for dorsal progenitors in cortical myelination

AU - Yue, Tao

AU - Xian, Kendy

AU - Hurlock, Edward

AU - Xin, Mei

AU - Kernie, Steven G.

AU - Parada, Luis F.

AU - Lu, Q. Richard

PY - 2006/1/25

Y1 - 2006/1/25

N2 - Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

AB - Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

KW - Cortex

KW - Knock-out mice

KW - Myelination

KW - Olig2

KW - Oligodendrocyte

KW - bHLH transcription factor

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A critical role for dorsal progenitors in cortical myelination

Abstract

Keywords

ASJC Scopus subject areas

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