A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery

Peter T. Tsai, John J. Ohab, Nathalie Kertesz, Matthias Groszer, Cheryl Matter, Jing Gao, Xin Liu, Hong Wu, S. Thomas Carmichael

Research output: Contribution to journalArticle

314 Scopus citations

Abstract

Erythropoietin (EPO) is the principal growth factor regulating the production of red blood cells. Recent studies demonstrated that exogenous EPO acts as a neuroprotectant and regulates neurogenesis. Using a genetic approach, we evaluate the roles of endogenous EPO and its classical receptor (EPOR) in mammalian neurogenesis. We demonstrate severe and identical embryonic neurogenesis defects in animals null for either the Epo or EpoR gene, suggesting that the classical EPOR is essential for EPO action during embryonic neurogenesis. Furthermore, by generating conditional EpoR knock-down animals, we demonstrate that brain-specific deletion of EpoR leads to significantly reduced cell proliferation in the subventricular zone and impaired post-stroke neurogenesis. EpoR conditional knockdown leads to a specific deficit in post-stroke neurogenesis through impaired migration of neuroblasts to the peri-infarct cortex. Our results suggest that both EPO and EPOR are essential for early embryonic neural development and that the classical EPOR is important for adult neurogenesis and for migration of regenerating neurons during post-injury recovery.

Original languageEnglish (US)
Pages (from-to)1269-1274
Number of pages6
JournalJournal of Neuroscience
Volume26
Issue number4
DOIs
StatePublished - Jan 25 2006

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Keywords

  • Erythropoietin
  • Erythropoietin receptor
  • Ischemia
  • Neurogenesis
  • Post-injury recovery
  • Subventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tsai, P. T., Ohab, J. J., Kertesz, N., Groszer, M., Matter, C., Gao, J., Liu, X., Wu, H., & Carmichael, S. T. (2006). A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. Journal of Neuroscience, 26(4), 1269-1274. https://doi.org/10.1523/JNEUROSCI.4480-05.2006