A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation

James Schuman, Yuhong Chen, Andrew Podd, Mei Yu, Hong Hsing Liu, Renren Wen, Zhijian J. Chen, Demin Wang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-κB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-κB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-κB activation.

Original languageEnglish (US)
Pages (from-to)4566-4574
Number of pages9
JournalBlood
Volume113
Issue number19
DOIs
StatePublished - 2009

Fingerprint

Cytoplasmic and Nuclear Receptors
B-Lymphocytes
Chemical activation
Cells
T-cells
T-Cell Antigen Receptor
Phosphotransferases
Apoptosis
Ligation
T-Lymphocytes

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Schuman, J., Chen, Y., Podd, A., Yu, M., Liu, H. H., Wen, R., ... Wang, D. (2009). A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation. Blood, 113(19), 4566-4574. https://doi.org/10.1182/blood-2008-08-176057

A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation. / Schuman, James; Chen, Yuhong; Podd, Andrew; Yu, Mei; Liu, Hong Hsing; Wen, Renren; Chen, Zhijian J.; Wang, Demin.

In: Blood, Vol. 113, No. 19, 2009, p. 4566-4574.

Research output: Contribution to journalArticle

Schuman, J, Chen, Y, Podd, A, Yu, M, Liu, HH, Wen, R, Chen, ZJ & Wang, D 2009, 'A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation', Blood, vol. 113, no. 19, pp. 4566-4574. https://doi.org/10.1182/blood-2008-08-176057
Schuman, James ; Chen, Yuhong ; Podd, Andrew ; Yu, Mei ; Liu, Hong Hsing ; Wen, Renren ; Chen, Zhijian J. ; Wang, Demin. / A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation. In: Blood. 2009 ; Vol. 113, No. 19. pp. 4566-4574.
@article{d75dfed73b9d405d91d38dbe382c4b45,
title = "A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation",
abstract = "The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-κB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-κB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-κB activation.",
author = "James Schuman and Yuhong Chen and Andrew Podd and Mei Yu and Liu, {Hong Hsing} and Renren Wen and Chen, {Zhijian J.} and Demin Wang",
year = "2009",
doi = "10.1182/blood-2008-08-176057",
language = "English (US)",
volume = "113",
pages = "4566--4574",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "19",

}

TY - JOUR

T1 - A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation

AU - Schuman, James

AU - Chen, Yuhong

AU - Podd, Andrew

AU - Yu, Mei

AU - Liu, Hong Hsing

AU - Wen, Renren

AU - Chen, Zhijian J.

AU - Wang, Demin

PY - 2009

Y1 - 2009

N2 - The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-κB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-κB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-κB activation.

AB - The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-κB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-κB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-κB activation.

UR - http://www.scopus.com/inward/record.url?scp=66549125216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66549125216&partnerID=8YFLogxK

U2 - 10.1182/blood-2008-08-176057

DO - 10.1182/blood-2008-08-176057

M3 - Article

VL - 113

SP - 4566

EP - 4574

JO - Blood

JF - Blood

SN - 0006-4971

IS - 19

ER -