A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation

James Schuman, Yuhong Chen, Andrew Podd, Mei Yu, Hong Hsing Liu, Renren Wen, Zhijian J. Chen, Demin Wang

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-κB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-κB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-κB activation.

Original languageEnglish (US)
Pages (from-to)4566-4574
Number of pages9
JournalBlood
Volume113
Issue number19
DOIs
StatePublished - Nov 17 2009

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Schuman, J., Chen, Y., Podd, A., Yu, M., Liu, H. H., Wen, R., Chen, Z. J., & Wang, D. (2009). A critical role of TAK1 in B-cell receptor-mediated nuclear factor κB activation. Blood, 113(19), 4566-4574. https://doi.org/10.1182/blood-2008-08-176057