A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

Siming Chen, Lianying Jiao, Xiuli Liu, Xin Yang, Xin Liu

Research output: Contribution to journalArticle

Abstract

PRC2 dimerization has long been noted, with unclear functions. Chen et al. reveal the structural basis of PRC2 dimerization in the context of PRC2-PCL (PRC2.1), which is drastically different from PRC2-AEBP2 (PRC2.2) in structural architecture. PRC2 dimerization controls CGI DNA binding in vitro and H3K27me3 deposition in vivo, possibly through an avidity effect.

Original languageEnglish (US)
Pages (from-to)1265-1278.e7
JournalMolecular cell
Volume77
Issue number6
DOIs
StatePublished - Mar 19 2020

Keywords

  • chromatin
  • CpG island (CGI)
  • crystal structure
  • epigenetics
  • gene silencing
  • histone methylation
  • polycomb repressive complex 2 (PRC2)
  • polycomb-like (PCL)
  • protein dimerization
  • structural biology

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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