Abstract
PRC2 dimerization has long been noted, with unclear functions. Chen et al. reveal the structural basis of PRC2 dimerization in the context of PRC2-PCL (PRC2.1), which is drastically different from PRC2-AEBP2 (PRC2.2) in structural architecture. PRC2 dimerization controls CGI DNA binding in vitro and H3K27me3 deposition in vivo, possibly through an avidity effect.
Original language | English (US) |
---|---|
Pages (from-to) | 1265-1278.e7 |
Journal | Molecular cell |
Volume | 77 |
Issue number | 6 |
DOIs | |
State | Published - Mar 19 2020 |
Keywords
- CpG island (CGI)
- chromatin
- crystal structure
- epigenetics
- gene silencing
- histone methylation
- polycomb repressive complex 2 (PRC2)
- polycomb-like (PCL)
- protein dimerization
- structural biology
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology