@article{d1a65ee911fc480091fcad8d771213c9,
title = "A discrete neuronal circuit induces a hibernation-like state in rodents",
abstract = "Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.",
author = "Takahashi, {Tohru M.} and Sunagawa, {Genshiro A.} and Shingo Soya and Manabu Abe and Katsuyasu Sakurai and Kiyomi Ishikawa and Masashi Yanagisawa and Hiroshi Hama and Emi Hasegawa and Atsushi Miyawaki and Kenji Sakimura and Masayo Takahashi and Takeshi Sakurai",
note = "Funding Information: Acknowledgements This study was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (JP 18H02595) (T.S.); a JSPS KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Willdynamics{\textquoteright} (16H06401); JSPS KAKENHI grant number JP19K22465 (T.S.); JST CREST grant number JPMJCR1655 Japan (T.S.); the RIKEN Special Postdoctoral Researcher program (G.A.S.); a JSPS KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Thermal Biology{\textquoteright} (18H04706) (G.A.S.); a JSPS KAKENHI Grant-in-Aid for Scientific Research (A) (19H01066) (G.A.S.); a research grant from the Astellas Foundation for Research on Metabolic Disorders (G.A.S.); and JSPS KAKENHI grant number 19J20876 (T.M.T.). We thank the animal resource centre at the University of Tsukuba and LARGE, RIKEN BDR for housing the mice; Y. Cherasse for preparing virus vectors; A. Miyasaka and Y. Niwa for discussion; and W. Gray for proofreading the manuscript. All of the brain diagrams used in figures were made based on the illustrations in Paxinos and Franklin{\textquoteright}s atlas of the mouse brain38 and Paxinos and Watson{\textquoteright}s atlas of the rat brain39. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2020",
month = jul,
day = "2",
doi = "10.1038/s41586-020-2163-6",
language = "English (US)",
volume = "583",
pages = "109--114",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7814",
}