A discriminant function for preeclampsia: Case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values

Karen P. Braun, Norman F. Gant, Camilla M. Olson, Valerie Parisi, Katherine A. Forrest, Charles M. Peterson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A case-control study was performed in eight pairs of women to determine whether preeclamptic women developed abnormalities in minor hemoglobins, glycolytic enzymes, or other blood components that might provide insight into the pathophysiology of preeclampsia, or that in combination might be used as a marker for the condition. These variables and standard clinical tests were analyzed as discriminators between preeclamptic and control women. The subjects were matched for age, ethnicity, parity, and gestational age. Blood samples were taken at the time of diagnosis of preeclampsia and at comparable gestational ages for matched normal controls. Variables differing significantly between groups included increases in uric acid (UA), low- density lipoproteins (LDL), phosphoglycerate kinase (PGK), and mean platelet volume (MPV), and decreases in glyceraldehyde phosphate dehydrogenase (G3PD) in preeclamptic women compared to normal controls. Discriminant analysis revealed the following function to separate the groups: 0.7764 (UA) + 0.8086 (PGK) 0.7032(G3PD) + 0.1399(LDL) -0.2386 (MPV). A discriminant score of ≤275 indicated a ≤90% probability of preeclampsia. The results are consistent with perturbations in red cell glycolysis in preeclampsia. Further prospective studies are warranted to test the efficacy of this discriminant function in predicting preeclampsia.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalAmerican Journal of Perinatology
Volume14
Issue number5
StatePublished - 1997

Fingerprint

Pre-Eclampsia
Case-Control Studies
Hemoglobins
Mean Platelet Volume
Phosphoglycerate Kinase
Enzymes
Uric Acid
LDL Lipoproteins
Gestational Age
Glyceraldehyde
Discriminant Analysis
Glycolysis
Parity
Oxidoreductases
Phosphates
Prospective Studies

Keywords

  • glycolytic enzymes
  • minor hemoglobins
  • Preeclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Braun, K. P., Gant, N. F., Olson, C. M., Parisi, V., Forrest, K. A., & Peterson, C. M. (1997). A discriminant function for preeclampsia: Case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values. American Journal of Perinatology, 14(5), 297-302.

A discriminant function for preeclampsia : Case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values. / Braun, Karen P.; Gant, Norman F.; Olson, Camilla M.; Parisi, Valerie; Forrest, Katherine A.; Peterson, Charles M.

In: American Journal of Perinatology, Vol. 14, No. 5, 1997, p. 297-302.

Research output: Contribution to journalArticle

Braun, KP, Gant, NF, Olson, CM, Parisi, V, Forrest, KA & Peterson, CM 1997, 'A discriminant function for preeclampsia: Case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values', American Journal of Perinatology, vol. 14, no. 5, pp. 297-302.
Braun, Karen P. ; Gant, Norman F. ; Olson, Camilla M. ; Parisi, Valerie ; Forrest, Katherine A. ; Peterson, Charles M. / A discriminant function for preeclampsia : Case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values. In: American Journal of Perinatology. 1997 ; Vol. 14, No. 5. pp. 297-302.
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