A double-blind, placebo-controlled study of pharmacological and behavioural treatment of lexical-semantic deficits in aphasia

M. R. Mcneil, P. J. Doyle, K. A. Spencer, A. Jackson Goda, D. Flores, S. L. Small

Research output: Contribution to journalArticle

43 Scopus citations


This investigation replicated and extended an earlier study of naming disorders by administering a placebo and pharmacological agents (d-amphetamine and selegiline) in the presence and absence of a behavioural intervention termed lexical-semantic activation inhibition therapy (L-SAIT) to examine their effects on naming performance in two adults with stroke-induced aphasia. Results revealed acquisition and maintenance effects of L-SAIT on targeted lexical items, no effects of placebo or active pharmacological agents in the absence of L-SAIT, and no differential effects between placebo + L-SAIT and pharmacological agents + L-SAIT. Thus, positive treatment effects were attributed to L-SAIT. Generalization to untrained items within and across form class was not observed, nor was generalization to measures of informativeness of connected speech. Subject 1 evidenced improvement on the Rapid Automatized Naming Test.

Original languageEnglish (US)
Pages (from-to)385-400
Number of pages16
Issue number4-5
Publication statusPublished - Jan 1 1997
Externally publishedYes


ASJC Scopus subject areas

  • Otorhinolaryngology
  • Language and Linguistics
  • Developmental and Educational Psychology
  • Linguistics and Language
  • Neurology
  • Clinical Neurology
  • LPN and LVN

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