A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song, Yunkou Wu, Mengxiao Yu, Piyu Zhao, Chen Zhou, Garry E. Kiefer, A. Dean Sherry

Research output: Contribution to journalArticle

23 Scopus citations


A europium(iii) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (1O2). The water soluble, thermodynamically stable complex reacts rapidly with 1O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(iii)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Original languageEnglish (US)
Pages (from-to)8066-8069
Number of pages4
JournalDalton Transactions
Issue number22
Publication statusPublished - Jun 14 2013


ASJC Scopus subject areas

  • Inorganic Chemistry

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