A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song, Yunkou Wu, Mengxiao Yu, Piyu Zhao, Chen Zhou, Garry E. Kiefer, A. Dean Sherry

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A europium(iii) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (1O2). The water soluble, thermodynamically stable complex reacts rapidly with 1O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(iii)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Original languageEnglish (US)
Pages (from-to)8066-8069
Number of pages4
JournalDalton Transactions
Volume42
Issue number22
DOIs
StatePublished - Jun 14 2013

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Europium
Singlet Oxygen
Magnetic resonance imaging
Derivatives
Water
Imaging techniques
Sensors

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI. / Song, Bo; Wu, Yunkou; Yu, Mengxiao; Zhao, Piyu; Zhou, Chen; Kiefer, Garry E.; Sherry, A. Dean.

In: Dalton Transactions, Vol. 42, No. 22, 14.06.2013, p. 8066-8069.

Research output: Contribution to journalArticle

Song, B, Wu, Y, Yu, M, Zhao, P, Zhou, C, Kiefer, GE & Sherry, AD 2013, 'A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI', Dalton Transactions, vol. 42, no. 22, pp. 8066-8069. https://doi.org/10.1039/c3dt50194a
Song B, Wu Y, Yu M, Zhao P, Zhou C, Kiefer GE et al. A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI. Dalton Transactions. 2013 Jun 14;42(22):8066-8069. https://doi.org/10.1039/c3dt50194a
Song, Bo ; Wu, Yunkou ; Yu, Mengxiao ; Zhao, Piyu ; Zhou, Chen ; Kiefer, Garry E. ; Sherry, A. Dean. / A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI. In: Dalton Transactions. 2013 ; Vol. 42, No. 22. pp. 8066-8069.
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