A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling

Atsuko Nakayama, Hiroyuki Morita, Tomoko Nakao, Toshihiro Yamaguchi, Tomokazu Sumida, Yuichi Ikeda, Hidetoshi Kumagai, Yoshihiro Motozawa, Tsukasa Takahashi, Atsushi Imaizumi, Tadashi Hashimoto, Ryozo Nagai, Issei Komuro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver. In this study, we clearly demonstrate that oral pretreatment with the higher-luteolin diet (0.035% (wt/wt)) protected against cardiac fibrosis and hypertrophy as well as a hyperoxidative state in Ang II-infused rats. In cardiac tissue, increased gene expression levels of TGFβ1, CTGF, Nox2, Nox4, ANP, and BNP induced by Ang II were restored by oral pretreatment of this high-luteolin diet. In cultured rat cardiac fibroblasts, H2O2-induced TGFβ1 expression and the phosphorylation of JNK were suppressed by luteolin pretreatment. In conclusion, food-derived luteolin has protective actions against Ang II-induced cardiac remodeling, which could be mediated through attenuation of oxidative stress.

Original languageEnglish (US)
Article numbere0137106
JournalPLoS One
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2015

Fingerprint

Luteolin
angiotensin II
luteolin
Flavonoids
Angiotensin II
flavonoids
Food
pretreatment
fibrosis
Oxidative stress
hypertrophy
Cardiomegaly
Nutrition
mouth
oxidative stress
Rats
Oxidative Stress
Perilla
Fibrosis
chamomile

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Nakayama, A., Morita, H., Nakao, T., Yamaguchi, T., Sumida, T., Ikeda, Y., ... Komuro, I. (2015). A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling. PLoS One, 10(9), [e0137106]. https://doi.org/10.1371/journal.pone.0137106

A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling. / Nakayama, Atsuko; Morita, Hiroyuki; Nakao, Tomoko; Yamaguchi, Toshihiro; Sumida, Tomokazu; Ikeda, Yuichi; Kumagai, Hidetoshi; Motozawa, Yoshihiro; Takahashi, Tsukasa; Imaizumi, Atsushi; Hashimoto, Tadashi; Nagai, Ryozo; Komuro, Issei.

In: PLoS One, Vol. 10, No. 9, e0137106, 01.09.2015.

Research output: Contribution to journalArticle

Nakayama, A, Morita, H, Nakao, T, Yamaguchi, T, Sumida, T, Ikeda, Y, Kumagai, H, Motozawa, Y, Takahashi, T, Imaizumi, A, Hashimoto, T, Nagai, R & Komuro, I 2015, 'A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling', PLoS One, vol. 10, no. 9, e0137106. https://doi.org/10.1371/journal.pone.0137106
Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y et al. A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling. PLoS One. 2015 Sep 1;10(9). e0137106. https://doi.org/10.1371/journal.pone.0137106
Nakayama, Atsuko ; Morita, Hiroyuki ; Nakao, Tomoko ; Yamaguchi, Toshihiro ; Sumida, Tomokazu ; Ikeda, Yuichi ; Kumagai, Hidetoshi ; Motozawa, Yoshihiro ; Takahashi, Tsukasa ; Imaizumi, Atsushi ; Hashimoto, Tadashi ; Nagai, Ryozo ; Komuro, Issei. / A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling. In: PLoS One. 2015 ; Vol. 10, No. 9.
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