A Foregut Carcinoid Tumor Causing Zollinger-Ellison Syndrome

G. B. Werbel, S. P. Nelson, P. G. Robinson, J. Anastasi, R. J. Joehl, Robert V Rege

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A patient had severe peptic ulcer disease complicated by gastric outlet obstruction and choledochoduodenal fistula. Serum gastrin levels were elevated preoperatively to 340 ng/L. A 1.5-cm histologically benign carcinoid tumor of the antrum of the stomach was found at surgery, and surgical resection of the tumor resulted in normalization of serum gastrin levels and amelioration of the peptic acid diathesis. The patient remains asymptomatic at one year. Immunohistochemical staining demonstrated that the carcinoid indeed contained gastrin along with chromogranin, cholecystokinin, and neuron-specific enolase. This is a case of Zollinger-Ellison syndrome caused by a benign foregut carcinoid (gastric carcinoid-gastrinoma).

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalArchives of Surgery
Volume124
Issue number3
DOIs
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Surgery

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    Werbel, G. B., Nelson, S. P., Robinson, P. G., Anastasi, J., Joehl, R. J., & Rege, R. V. (1989). A Foregut Carcinoid Tumor Causing Zollinger-Ellison Syndrome. Archives of Surgery, 124(3), 381-384. https://doi.org/10.1001/archsurg.1989.01410030131022