A fork in the road to fertility

R. L. Prueitt, A. R. Zinn

Research output: Contribution to journalShort survey

45 Scopus citations

Abstract

Haploinsufficiency of FOXL2, a new forkhead transcription factor, causes blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), a rare developmental disorder affecting the eyelid and sometimes the ovary. A new study implicates FOXL2 as the first human gene required for the maintenance of ovarian follicles. The discovery of FOXL2 may provide insight into the causes of idiopathic premature ovarian failure, a disease that burdens many infertile couples.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalNature genetics
Volume27
Issue number2
DOIs
StatePublished - Feb 27 2001

ASJC Scopus subject areas

  • Genetics

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