A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits

B. E. Snow; A. M. Krumins; G. M. Brothers; S. F. Lee; M. A. Wall; S. Chung; J. Mangion; S. Arya; A. G. Gilman; D. P. Siderovski

doi:10.1073/pnas.95.22.13307

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits

B. E. Snow, A. M. Krumins, G. M. Brothers, S. F. Lee, M. A. Wall, S. Chung, J. Mangion, S. Arya, A. G. Gilman, D. P. Siderovski

Pharmacology

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233 Scopus citations

Abstract

Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the α subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein γ subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different G_β subunits reveals specific interaction between RGS11 and G_β5. The expression of mRNA for RGS11 and G_β5 in human tissues overlaps. The G_β5/RGS11 heterodimer acts as a GAP on G_αo, apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for G_α proteins and form complexes with specific G_β subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.

Original language	English (US)
Pages (from-to)	13307-13312
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	95
Issue number	22
DOIs	https://doi.org/10.1073/pnas.95.22.13307
State	Published - Oct 27 1998

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Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S. F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G., & Siderovski, D. P. (1998). A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits. Proceedings of the National Academy of Sciences of the United States of America, 95(22), 13307-13312. https://doi.org/10.1073/pnas.95.22.13307

Snow, BE, Krumins, AM, Brothers, GM, Lee, SF, Wall, MA, Chung, S, Mangion, J, Arya, S, Gilman, AG & Siderovski, DP 1998, 'A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits', Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 22, pp. 13307-13312. https://doi.org/10.1073/pnas.95.22.13307

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abstract = "Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the α subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein γ subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different Gβ subunits reveals specific interaction between RGS11 and Gβ5. The expression of mRNA for RGS11 and Gβ5 in human tissues overlaps. The Gβ5/RGS11 heterodimer acts as a GAP on Gαo, apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for Gα proteins and form complexes with specific Gβ subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.",

author = "Snow, {B. E.} and Krumins, {A. M.} and Brothers, {G. M.} and Lee, {S. F.} and Wall, {M. A.} and S. Chung and J. Mangion and S. Arya and Gilman, {A. G.} and Siderovski, {D. P.}",

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AU - Brothers, G. M.

AU - Lee, S. F.

AU - Wall, M. A.

AU - Chung, S.

AU - Mangion, J.

AU - Arya, S.

AU - Gilman, A. G.

AU - Siderovski, D. P.

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N2 - Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the α subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein γ subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different Gβ subunits reveals specific interaction between RGS11 and Gβ5. The expression of mRNA for RGS11 and Gβ5 in human tissues overlaps. The Gβ5/RGS11 heterodimer acts as a GAP on Gαo, apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for Gα proteins and form complexes with specific Gβ subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.

AB - Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the α subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein γ subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different Gβ subunits reveals specific interaction between RGS11 and Gβ5. The expression of mRNA for RGS11 and Gβ5 in human tissues overlaps. The Gβ5/RGS11 heterodimer acts as a GAP on Gαo, apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for Gα proteins and form complexes with specific Gβ subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.

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A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits

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