A general synthesis of 1,7-disubstituted 1,4,7,10-tetraazacyclododecanes

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Abstract

1,4,7,10-Tetraazacyclododecane reacts regioselectively in acid solution with several chloroformates to give 1,7-diprotected derivatives which could be alkylated and deprotected to afford 1,7-disubstituted 1,4,7,10- tetraazacyclododecanes.

Original languageEnglish (US)
Pages (from-to)185-186
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number2
DOIs
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Molecular Medicine

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