A genetic basis for atrophy: Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice

P. Sutton, J. Wilson, R. Genta, D. Torrey, A. Savinainen, J. Pappo, A. Lee

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background - The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. Aims - To investigate these host factors further by using genetic crosses of responder and non-responder mice. Methods - F1 hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected for three months with H felis. Gastritis was assessed by histopathology and serum antibody responses by ELISA. Results - Infection of CBA/Ca mice and F1 hybrids induced little or no gastritis. Analyses of the antibody responses in these mice revealed virtually undetectable anti-helicobacter antibody levels despite colonisation with high numbers of H felis. In contrast, infection of H felis responsive strains induced gastritis and a significant humoral immune response. Conclusions - The non-responsiveness of CBA/Ca mice to H felis infection is dominantly inherited. The lack of gastritis in GBA mice and their offspring is probably due to active suppression of the immune response normally mounted against H felis. Investigation of these mechanisms will provide important insights relevant to induction of gastric atrophy and cancer in humans.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalGut
Volume45
Issue number3
StatePublished - 1999

Fingerprint

Helicobacter
Felis
Gastritis
Atrophy
Inbred CBA Mouse
Infection
Antibody Formation
Helicobacter felis
Active Immunity
Genetic Crosses
Atrophic Gastritis
Humoral Immunity
Stomach Neoplasms
Anti-Idiotypic Antibodies
Animal Models
Enzyme-Linked Immunosorbent Assay
Serum

Keywords

  • CBA
  • F hybrid
  • Gastritis
  • Helicobacter
  • Non-responsiveness

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sutton, P., Wilson, J., Genta, R., Torrey, D., Savinainen, A., Pappo, J., & Lee, A. (1999). A genetic basis for atrophy: Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice. Gut, 45(3), 335-340.

A genetic basis for atrophy : Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice. / Sutton, P.; Wilson, J.; Genta, R.; Torrey, D.; Savinainen, A.; Pappo, J.; Lee, A.

In: Gut, Vol. 45, No. 3, 1999, p. 335-340.

Research output: Contribution to journalArticle

Sutton, P, Wilson, J, Genta, R, Torrey, D, Savinainen, A, Pappo, J & Lee, A 1999, 'A genetic basis for atrophy: Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice', Gut, vol. 45, no. 3, pp. 335-340.
Sutton P, Wilson J, Genta R, Torrey D, Savinainen A, Pappo J et al. A genetic basis for atrophy: Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice. Gut. 1999;45(3):335-340.
Sutton, P. ; Wilson, J. ; Genta, R. ; Torrey, D. ; Savinainen, A. ; Pappo, J. ; Lee, A. / A genetic basis for atrophy : Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice. In: Gut. 1999 ; Vol. 45, No. 3. pp. 335-340.
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