A genomic view of the human-Bacteroides thetaiotaomicron symbiosis

Jian Xu, Magnus K. Bjursell, Jason Himrod, Su Deng, Lynn K. Carmichael, Herbert C. Chiang, Lora V. Hooper, Jeffrey I. Gordon

Research output: Contribution to journalArticle

803 Citations (Scopus)

Abstract

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

Original languageEnglish (US)
Pages (from-to)2074-2076
Number of pages3
JournalScience
Volume299
Issue number5615
DOIs
StatePublished - Mar 28 2003

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Sigma Factor
Symbiosis
Proteome
Intestines
Polysaccharides
Signal Transduction
Genome
Gastrointestinal Microbiome
Bacteroides thetaiotaomicron

ASJC Scopus subject areas

  • General

Cite this

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., ... Gordon, J. I. (2003). A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science, 299(5615), 2074-2076. https://doi.org/10.1126/science.1080029

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. / Xu, Jian; Bjursell, Magnus K.; Himrod, Jason; Deng, Su; Carmichael, Lynn K.; Chiang, Herbert C.; Hooper, Lora V.; Gordon, Jeffrey I.

In: Science, Vol. 299, No. 5615, 28.03.2003, p. 2074-2076.

Research output: Contribution to journalArticle

Xu, J, Bjursell, MK, Himrod, J, Deng, S, Carmichael, LK, Chiang, HC, Hooper, LV & Gordon, JI 2003, 'A genomic view of the human-Bacteroides thetaiotaomicron symbiosis', Science, vol. 299, no. 5615, pp. 2074-2076. https://doi.org/10.1126/science.1080029
Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC et al. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science. 2003 Mar 28;299(5615):2074-2076. https://doi.org/10.1126/science.1080029
Xu, Jian ; Bjursell, Magnus K. ; Himrod, Jason ; Deng, Su ; Carmichael, Lynn K. ; Chiang, Herbert C. ; Hooper, Lora V. ; Gordon, Jeffrey I. / A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. In: Science. 2003 ; Vol. 299, No. 5615. pp. 2074-2076.
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