A High Degree of HLA Disparity Arises From Limited Allelic Diversity: Analysis of 1775 Unrelated Bone Marrow Transplant Donor-Recipient Pairs

Carolyn Katovich Hurley, Marcelo Fernandez-Vina, William H. Hildebrand, Harriet J. Noreen, Elizabeth Trachtenberg, Thomas M. Williams, Lee Ann Baxter-Lowe, Ann B. Begovich, Effie Petersdorf, Annamalai Selvakumar, Peter Stastny, Janet Hegland, Robert J. Hartzman, Michael Carston, Sharavi Gandham, Craig Kollman, Gene Nelson, Stephen Spellman, Michelle Setterholm

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analysis included the class I (A, B, C) and II (DRB1, DQA1, DQB1, DPA1, DPB1) loci. Most (>66%) of the predominantly Caucasian study population carried one or two of five to seven common alleles at each HLA locus. In spite of this limited diversity, 29% of the six of six antigen-matched transplants carried allele mismatches at HLA-A, -B, and/or -DRB1, and 92% carried at least one allele mismatch at one of the eight HLA loci tested. Of the 968 HLA-A,-B,-DRB1 allele-matched pairs, 89% carried mismatches at other HLA loci, predominantly at DP loci. The substantially greater than expected HLA allelic disparity between donor and recipient suggests extensive haplotypic diversity and underscores the importance of enhancing approaches to mitigate the deleterious effect of HLA mismatches.

Original languageEnglish (US)
Pages (from-to)30-40
Number of pages11
JournalHuman Immunology
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Bone marrow transplantation
  • HLA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'A High Degree of HLA Disparity Arises From Limited Allelic Diversity: Analysis of 1775 Unrelated Bone Marrow Transplant Donor-Recipient Pairs'. Together they form a unique fingerprint.

  • Cite this

    Hurley, C. K., Fernandez-Vina, M., Hildebrand, W. H., Noreen, H. J., Trachtenberg, E., Williams, T. M., Baxter-Lowe, L. A., Begovich, A. B., Petersdorf, E., Selvakumar, A., Stastny, P., Hegland, J., Hartzman, R. J., Carston, M., Gandham, S., Kollman, C., Nelson, G., Spellman, S., & Setterholm, M. (2007). A High Degree of HLA Disparity Arises From Limited Allelic Diversity: Analysis of 1775 Unrelated Bone Marrow Transplant Donor-Recipient Pairs. Human Immunology, 68(1), 30-40. https://doi.org/10.1016/j.humimm.2006.09.004