A History of Bone Marrow Transplantation

M. Teresa de la Morena, Richard A. Gatti

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalImmunology and Allergy Clinics of North America
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2010

Keywords

  • Bone marrow transplantation
  • History
  • Primary immunodeficiency diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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