A History of Bone Marrow Transplantation

M. Teresa de la Morena, Richard A. Gatti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalImmunology and Allergy Clinics of North America
Volume30
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Bone Marrow Transplantation
Investigational Therapies
Hematopoietic Stem Cell Transplantation
Hematologic Neoplasms
Hematopoietic Stem Cells
Life Expectancy
Quality of Life
Research Personnel
Transplants
Therapeutics
Oncologists

Keywords

  • Bone marrow transplantation
  • History
  • Primary immunodeficiency diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

A History of Bone Marrow Transplantation. / de la Morena, M. Teresa; Gatti, Richard A.

In: Immunology and Allergy Clinics of North America, Vol. 30, No. 1, 02.2010, p. 1-15.

Research output: Contribution to journalArticle

de la Morena, M. Teresa ; Gatti, Richard A. / A History of Bone Marrow Transplantation. In: Immunology and Allergy Clinics of North America. 2010 ; Vol. 30, No. 1. pp. 1-15.
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