A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu, Kimberly H. Cox, Joseph S Takahashi

Research output: Contribution to journalShort survey


Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

Original languageEnglish (US)
JournalTrends in Neurosciences
Publication statusPublished - Jan 1 2019



  • Drosophila
  • redox state
  • sleep switch

ASJC Scopus subject areas

  • Neuroscience(all)

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