A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu; Kimberly H. Cox; Joseph S. Takahashi

doi:10.1016/j.tins.2019.05.007

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu, Kimberly H. Cox, Joseph S. Takahashi

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

Original language	English (US)
Pages (from-to)	514-517
Number of pages	4
Journal	Trends in Neurosciences
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.tins.2019.05.007
State	Published - Aug 2019

Keywords

Drosophila
NADPH
redox state
sleep switch

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.tins.2019.05.007

Cite this

@article{405dd78438a2434580bd50dcb57a9e0a,

title = "A Hyperkinetic Redox Sensor Drives Flies to Sleep",

abstract = "Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.",

keywords = "Drosophila, NADPH, redox state, sleep switch",

author = "Pin Xu and Cox, {Kimberly H.} and Takahashi, {Joseph S.}",

note = "Funding Information: J.S.T. is supported by the National Institutes of Health ( R01 AG045795 and R01 NS106657 ) and is an Investigator in the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = aug,

doi = "10.1016/j.tins.2019.05.007",

language = "English (US)",

volume = "42",

pages = "514--517",

journal = "Trends in Neurosciences",

issn = "0378-5912",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - A Hyperkinetic Redox Sensor Drives Flies to Sleep

AU - Xu, Pin

AU - Cox, Kimberly H.

AU - Takahashi, Joseph S.

N1 - Funding Information: J.S.T. is supported by the National Institutes of Health ( R01 AG045795 and R01 NS106657 ) and is an Investigator in the Howard Hughes Medical Institute. Publisher Copyright: © 2019

PY - 2019/8

Y1 - 2019/8

N2 - Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

AB - Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

KW - Drosophila

KW - NADPH

KW - redox state

KW - sleep switch

UR - http://www.scopus.com/inward/record.url?scp=85066814551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066814551&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2019.05.007

DO - 10.1016/j.tins.2019.05.007

M3 - Short survey

C2 - 31178075

AN - SCOPUS:85066814551

SN - 0378-5912

VL - 42

SP - 514

EP - 517

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 8

ER -

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this