A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu, Kimberly H. Cox, Joseph S. Takahashi

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalTrends in Neurosciences
Issue number8
StatePublished - Aug 2019


  • Drosophila
  • redox state
  • sleep switch

ASJC Scopus subject areas

  • Neuroscience(all)


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