Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.
|Original language||English (US)|
|Number of pages||4|
|Journal||Trends in Neurosciences|
|State||Published - Aug 2019|
- redox state
- sleep switch
ASJC Scopus subject areas