A Kinase Divided

Aroon S. Karra, Clinton A. Taylor, Curtis A. Thorne, Melanie H. Cobb

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalCancer Cell
Volume28
Issue number2
DOIs
StatePublished - Aug 10 2015

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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