A large family of divergent Drosophila odorant-binding proteins expressed in gustatory and olfactory sensilla

Kathleen Galindo, Dean P. Smith

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

We identified a large family of putative odorant-binding protein (OBP) genes in the genome of Drosophila melanogaster. Some of these genes are present in large clusters in the genome. Most members are expressed in various taste organs, including gustatory sensilla in the labellum, the pharyngeal labral sense organ, dorsal and ventral cibarial organs, as well as taste bristles located on the wings and tarsi. Some of the gustatory OBPs are expressed exclusively in taste organs, but most are expressed in both olfactory and gustatory sensilla. Multiple binding proteins can be coexpressed in the same gustatory sensillum. Cells in the tarsi that express OBPs are required for normal chemosensation mediated through the leg, as ablation of these cells dramatically reduces the sensitivity of the proboscis extension reflex to sucrose. Finally, we show that OBP genes expressed in the pharyngeal taste sensilla are still expressed in the poxneuro genetic background while OBPs expressed in the labellum are not. These findings support a broad role for members of the OBP family in gustation and olfaction and suggest that poxneuro is required for cell fate determination of labellar but not pharyngeal taste organs.

Original languageEnglish (US)
Pages (from-to)1059-1072
Number of pages14
JournalGenetics
Volume159
Issue number3
StatePublished - 2001

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Sensilla
Ankle
odorant-binding protein
Sense Organs
Genome
Genes
Smell
Drosophila melanogaster
Reflex
Sucrose
Leg
Carrier Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A large family of divergent Drosophila odorant-binding proteins expressed in gustatory and olfactory sensilla. / Galindo, Kathleen; Smith, Dean P.

In: Genetics, Vol. 159, No. 3, 2001, p. 1059-1072.

Research output: Contribution to journalArticle

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