A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinement

Jeffrey C. Xing, Justin A. Bishop, Nestoras Mathioudakis, Nishant Agrawal, Ralph P. Tufano

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Abstract

Anaplastic thyroid cancer (ATC) is rare but extremely aggressive, which accounts for about 2% of all thyroid cancers yet nearly 50% of thyroid-cancer-associated deaths in the United States. The median survival time from diagnosis is 5 months, with a 1-year survival rate of only 20%. We report here a case of ATC in a 56-year-old man who survived a large ATC. Preoperative fine-needle aspiration biopsy study to a large right thyroid mass suggested ATC. Total thyroidectomy with radical lateral neck and central neck dissection removed a well-circumscribed 9.5cm tumor without extrathyroidal extension or lymphovascular invasion. All 73 lymph nodes removed were negative for metastasis. The tumor consisted of highly pleomorphic, undifferentiated cells with large zones of necrosis and loss of thyroid transcription factor-1 and thyroglobulin expression. A focal well-differentiated component and PAX8 expression confirmed its thyroid follicular cell origin. Nine months after postsurgical adjuvant concurrent radiation therapy and chemotherapy, the patient remained well without clinical, biochemical, and radiographical evidence for cancer recurrence. This is an unusual case of ATC in that it is one of the largest ATC tumors reported to display mild pathologic behavior and relatively long-term patient survival.

Original languageEnglish (US)
Article number583978
JournalCase Reports in Medicine
Volume2011
DOIs
StatePublished - Jan 1 2011

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Thyroid Neoplasms
Neoplasms
Neck Dissection
Survival
Thyroglobulin
Thyroidectomy
Fine Needle Biopsy
Anaplastic Thyroid Carcinoma
Thyroid Gland
Necrosis
Neck
Radiotherapy
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Recurrence
Drug Therapy
thyroid nuclear factor 1
Thyroid Epithelial Cells

ASJC Scopus subject areas

  • Medicine(all)

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A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinement. / Xing, Jeffrey C.; Bishop, Justin A.; Mathioudakis, Nestoras; Agrawal, Nishant; Tufano, Ralph P.

In: Case Reports in Medicine, Vol. 2011, 583978, 01.01.2011.

Research output: Contribution to journalArticle

Xing, Jeffrey C. ; Bishop, Justin A. ; Mathioudakis, Nestoras ; Agrawal, Nishant ; Tufano, Ralph P. / A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinement. In: Case Reports in Medicine. 2011 ; Vol. 2011.
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