A low threshold calcium spike mediates firing pattern alterations in pontine reticular neurons

Robert W. Greene, Helmut L. Haas, Robert W. McCarley, H. L. Haas

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Intracellular electrical recordings in an in vitro slice preparation of the brainstem medial pontine reticular formation, a region thought to be important in mediation of desynchronized sleep phenomena, demonstrate a population of neurons that have a calcium-dependent, low threshold spike. This low threshold spike was inactivated at relatively depolarized membrane potential levels and, when this spike was deinactivated, it induced a burst of action potentials. The membrane potential dependence of the spike may underlie changes in action potential firing patterns associated with behavioral state change because the baseline membrane potential in neurons of the medial pontine reticular population depolarizes during passage from waking and slow wave sleep to desynchronized sleep, which is characterized by the absence of burst firing.

Original languageEnglish (US)
Pages (from-to)738-740
Number of pages3
JournalScience
Volume234
Issue number4777
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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