A magnetic resonance imaging study of putamen nuclei in major depression

Mustafa M. Husain, William M. McDonald, P. Murali Doraiswamy, Gary S. Figiel, Chul Na, P. Rodrigo Escalona, Orest B. Boyko, Charles B. Nemeroff, K. Ranga R Krishnan

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depressive mood, and psychosis. Using high resolution, axial T2 intermediate magnetic resonance images, and a systematic sampling stereologic method, we assessed putamen nuclei volumes in 41 patients with major depression (DSM-III) and 44 healthy volunteer controls of similar age. Depressed patients had significantly smaller putamen nuclei compared with controls. Age was negatively correlated with putamen size in both groups. These results are the first demonstration of diminished putamen volumes in depression and further support a role for basal ganglia structures in the etiopathogenesis of depression.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalPsychiatry Research
Volume40
Issue number2
StatePublished - Oct 1991

Fingerprint

Putamen
Basal Ganglia
Magnetic Resonance Imaging
Depression
Apathy
Behavioral Symptoms
Neurobehavioral Manifestations
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Healthy Volunteers
Magnetic Resonance Spectroscopy

Keywords

  • basal ganglia
  • limbic system
  • Magnetic resonance imaging
  • major depression
  • putamen nuclei

ASJC Scopus subject areas

  • Psychology(all)
  • Biological Psychiatry
  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging

Cite this

Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Na, C., Escalona, P. R., ... Krishnan, K. R. R. (1991). A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Research, 40(2), 95-99.

A magnetic resonance imaging study of putamen nuclei in major depression. / Husain, Mustafa M.; McDonald, William M.; Doraiswamy, P. Murali; Figiel, Gary S.; Na, Chul; Escalona, P. Rodrigo; Boyko, Orest B.; Nemeroff, Charles B.; Krishnan, K. Ranga R.

In: Psychiatry Research, Vol. 40, No. 2, 10.1991, p. 95-99.

Research output: Contribution to journalArticle

Husain, MM, McDonald, WM, Doraiswamy, PM, Figiel, GS, Na, C, Escalona, PR, Boyko, OB, Nemeroff, CB & Krishnan, KRR 1991, 'A magnetic resonance imaging study of putamen nuclei in major depression', Psychiatry Research, vol. 40, no. 2, pp. 95-99.
Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Na C, Escalona PR et al. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Research. 1991 Oct;40(2):95-99.
Husain, Mustafa M. ; McDonald, William M. ; Doraiswamy, P. Murali ; Figiel, Gary S. ; Na, Chul ; Escalona, P. Rodrigo ; Boyko, Orest B. ; Nemeroff, Charles B. ; Krishnan, K. Ranga R. / A magnetic resonance imaging study of putamen nuclei in major depression. In: Psychiatry Research. 1991 ; Vol. 40, No. 2. pp. 95-99.
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