A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.

Sara Chirayil; Veronica Clavijo Jordan; André F. Martins; Namini Paranawithana; S. James Ratnakar; A. Dean Sherry

doi:10.26434/chemrxiv.12430082.v1

A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.

Sara Chirayil, Veronica Clavijo Jordan, André F. Martins, Namini Paranawithana, S. James Ratnakar, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

Abstract

A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized and the agent was used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that Mn(PyC3A-BPEN) has superior kinetic inertness compared to Gd(DTPA), is less susceptible to transmetallation in the presence of excess Zn²⁺ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, Mn(PyC3A-BPEN) appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from prostate cells.

Original language	English (US)
Journal	Unknown Journal
DOIs	https://doi.org/10.26434/chemrxiv.12430082.v1
State	Published - Jun 4 2020

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Materials Science(all)

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title = "A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.",

abstract = "A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized and the agent was used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that Mn(PyC3A-BPEN) has superior kinetic inertness compared to Gd(DTPA), is less susceptible to transmetallation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, Mn(PyC3A-BPEN) appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from prostate cells.",

author = "Sara Chirayil and Jordan, {Veronica Clavijo} and Martins, {Andr{\'e} F.} and Namini Paranawithana and Ratnakar, {S. James} and Sherry, {A. Dean}",

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doi = "10.26434/chemrxiv.12430082.v1",

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T1 - A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.

AU - Chirayil, Sara

AU - Jordan, Veronica Clavijo

AU - Martins, André F.

AU - Paranawithana, Namini

AU - Ratnakar, S. James

AU - Sherry, A. Dean

PY - 2020/6/4

Y1 - 2020/6/4

N2 - A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized and the agent was used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that Mn(PyC3A-BPEN) has superior kinetic inertness compared to Gd(DTPA), is less susceptible to transmetallation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, Mn(PyC3A-BPEN) appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from prostate cells.

AB - A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized and the agent was used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that Mn(PyC3A-BPEN) has superior kinetic inertness compared to Gd(DTPA), is less susceptible to transmetallation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, Mn(PyC3A-BPEN) appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from prostate cells.

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