A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells

Shizhen Emily Wang; Peter Hinow; Nicole Bryce; Alissa M. Weaver; Lourdes Estrada; Carlos L. Arteaga; Glenn F. Webb

doi:10.1080/17486700802171993

A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells

Shizhen Emily Wang, Peter Hinow, Nicole Bryce, Alissa M. Weaver, Lourdes Estrada, Carlos L. Arteaga, Glenn F. Webb

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Transforming growth factor (TGF)-beta; is known to have properties of both a tumour suppressor and a tumour promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell-cell adhesion. Coupling mathematical modelling and experiments, we investigate the growth and motility of oncogene-expressing human mammary epithelial cells under exposure to TGF-beta;. We use a version of the well-known Fisher-Kolmogorov equation, and prescribe a procedure for its parametrisation. We quantify the simultaneous effects of TGF-beta; to increase the tendency of individual cells and cell clusters to move randomly and to decrease overall population growth. We demonstrate that in experiments with TGF-beta; treated cells in vitro, TGF-beta; increases cell motility by a factor of 2 and decreases cell proliferation by a factor of 1/2 in comparison with untreated cells.

Original language	English (US)
Pages (from-to)	71-83
Number of pages	13
Journal	Computational and Mathematical Methods in Medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/17486700802171993
State	Published - 2009

Keywords

Cell growth and motility
Fisher-Kolmogorov equation
Mathematical model
Transforming growth factor (TGF)-beta;

ASJC Scopus subject areas

Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
Applied Mathematics

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10.1080/17486700802171993

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abstract = "Transforming growth factor (TGF)-beta; is known to have properties of both a tumour suppressor and a tumour promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell-cell adhesion. Coupling mathematical modelling and experiments, we investigate the growth and motility of oncogene-expressing human mammary epithelial cells under exposure to TGF-beta;. We use a version of the well-known Fisher-Kolmogorov equation, and prescribe a procedure for its parametrisation. We quantify the simultaneous effects of TGF-beta; to increase the tendency of individual cells and cell clusters to move randomly and to decrease overall population growth. We demonstrate that in experiments with TGF-beta; treated cells in vitro, TGF-beta; increases cell motility by a factor of 2 and decreases cell proliferation by a factor of 1/2 in comparison with untreated cells.",

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AU - Wang, Shizhen Emily

AU - Hinow, Peter

AU - Bryce, Nicole

AU - Weaver, Alissa M.

AU - Estrada, Lourdes

AU - Arteaga, Carlos L.

AU - Webb, Glenn F.

PY - 2009

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AB - Transforming growth factor (TGF)-beta; is known to have properties of both a tumour suppressor and a tumour promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell-cell adhesion. Coupling mathematical modelling and experiments, we investigate the growth and motility of oncogene-expressing human mammary epithelial cells under exposure to TGF-beta;. We use a version of the well-known Fisher-Kolmogorov equation, and prescribe a procedure for its parametrisation. We quantify the simultaneous effects of TGF-beta; to increase the tendency of individual cells and cell clusters to move randomly and to decrease overall population growth. We demonstrate that in experiments with TGF-beta; treated cells in vitro, TGF-beta; increases cell motility by a factor of 2 and decreases cell proliferation by a factor of 1/2 in comparison with untreated cells.

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A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells

Abstract

Keywords

ASJC Scopus subject areas

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