A mesoscopic description of contractile cytoskeletal meshworks

K. Doubrovinski, O. Polyakov, M. Kaschube

Research output: Contribution to journalArticle

Abstract

Epithelial morphogenesis plays a major role in embryonic development. During this process cells within epithelial sheets undergo complex spatial reorganization to form organs with specific shapes and functions. The dynamics of epithelial cell reorganization is driven by forces generated through the cytoskeleton, an active network of polar filaments and motor proteins. Over the relevant time scales, individual cytoskeletal filaments typically undergo turnover, where existing filaments depolymerize into monomers and new filaments are nucleated. Here we extend a previously developed physical description of the force generation by the cytoskeleton to account for the effects of filament turnover. We find that filament turnover can significantly stabilize contractile structures against rupture and discuss several possible routes to instability resulting in the rupture of the cytoskeletal meshwork. Additionally, we show that our minimal description can account for a range of phenomena that were recently observed in fruit fly epithelial morphogenesis.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalEuropean Physical Journal E
Volume33
Issue number2
DOIs
StatePublished - Oct 1 2010

Fingerprint

Cytoskeleton
filaments
Morphogenesis
Active networks
Rupture
Fruits
Epithelial Cells
Monomers
Proteins
Embryonic Development
Fruit
fruits
organs
monomers
routes
proteins
cells

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Chemistry(all)
  • Materials Science(all)
  • Surfaces and Interfaces

Cite this

A mesoscopic description of contractile cytoskeletal meshworks. / Doubrovinski, K.; Polyakov, O.; Kaschube, M.

In: European Physical Journal E, Vol. 33, No. 2, 01.10.2010, p. 105-110.

Research output: Contribution to journalArticle

Doubrovinski, K. ; Polyakov, O. ; Kaschube, M. / A mesoscopic description of contractile cytoskeletal meshworks. In: European Physical Journal E. 2010 ; Vol. 33, No. 2. pp. 105-110.
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