Abstract
Epithelial morphogenesis plays a major role in embryonic development. During this process cells within epithelial sheets undergo complex spatial reorganization to form organs with specific shapes and functions. The dynamics of epithelial cell reorganization is driven by forces generated through the cytoskeleton, an active network of polar filaments and motor proteins. Over the relevant time scales, individual cytoskeletal filaments typically undergo turnover, where existing filaments depolymerize into monomers and new filaments are nucleated. Here we extend a previously developed physical description of the force generation by the cytoskeleton to account for the effects of filament turnover. We find that filament turnover can significantly stabilize contractile structures against rupture and discuss several possible routes to instability resulting in the rupture of the cytoskeletal meshwork. Additionally, we show that our minimal description can account for a range of phenomena that were recently observed in fruit fly epithelial morphogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-110 |
| Number of pages | 6 |
| Journal | European Physical Journal E |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2010 |
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ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Chemistry(all)
- Materials Science(all)
- Surfaces and Interfaces
Cite this
A mesoscopic description of contractile cytoskeletal meshworks. / Doubrovinski, K.; Polyakov, O.; Kaschube, M.
In: European Physical Journal E, Vol. 33, No. 2, 01.10.2010, p. 105-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A mesoscopic description of contractile cytoskeletal meshworks
AU - Doubrovinski, K.
AU - Polyakov, O.
AU - Kaschube, M.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Epithelial morphogenesis plays a major role in embryonic development. During this process cells within epithelial sheets undergo complex spatial reorganization to form organs with specific shapes and functions. The dynamics of epithelial cell reorganization is driven by forces generated through the cytoskeleton, an active network of polar filaments and motor proteins. Over the relevant time scales, individual cytoskeletal filaments typically undergo turnover, where existing filaments depolymerize into monomers and new filaments are nucleated. Here we extend a previously developed physical description of the force generation by the cytoskeleton to account for the effects of filament turnover. We find that filament turnover can significantly stabilize contractile structures against rupture and discuss several possible routes to instability resulting in the rupture of the cytoskeletal meshwork. Additionally, we show that our minimal description can account for a range of phenomena that were recently observed in fruit fly epithelial morphogenesis.
AB - Epithelial morphogenesis plays a major role in embryonic development. During this process cells within epithelial sheets undergo complex spatial reorganization to form organs with specific shapes and functions. The dynamics of epithelial cell reorganization is driven by forces generated through the cytoskeleton, an active network of polar filaments and motor proteins. Over the relevant time scales, individual cytoskeletal filaments typically undergo turnover, where existing filaments depolymerize into monomers and new filaments are nucleated. Here we extend a previously developed physical description of the force generation by the cytoskeleton to account for the effects of filament turnover. We find that filament turnover can significantly stabilize contractile structures against rupture and discuss several possible routes to instability resulting in the rupture of the cytoskeletal meshwork. Additionally, we show that our minimal description can account for a range of phenomena that were recently observed in fruit fly epithelial morphogenesis.
UR - http://www.scopus.com/inward/record.url?scp=78649987240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649987240&partnerID=8YFLogxK
U2 - 10.1140/epje/i2010-10655-6
DO - 10.1140/epje/i2010-10655-6
M3 - Article
C2 - 20878438
AN - SCOPUS:78649987240
VL - 33
SP - 105
EP - 110
JO - European Physical Journal E
JF - European Physical Journal E
SN - 1292-8941
IS - 2
ER -