A method for campus-wide SARS-CoV-2 surveillance at a large public university

Terren Chang; Jolene M. Draper; Anouk van den Bout; Ellen Kephart; Hannah Maul-Newby; Yvonne Vasquez; Jason Woodbury; Savanna Randi; Martina Pedersen; Maeve Nave; Scott La; Natalie Gallagher; Molly M. McCabe; Namrita Dhillon; Isabel Bjork; Michael Luttrell; Frank Dang; John B. MacMillan; Ralph Green; Elizabeth Miller; Auston M. Kilpatrick; Olena Vaske; Michael D. Stone; Jeremy R. Sanford

doi:10.1371/journal.pone.0261230

A method for campus-wide SARS-CoV-2 surveillance at a large public university

Terren Chang, Jolene M. Draper, Anouk van den Bout, Ellen Kephart, Hannah Maul-Newby, Yvonne Vasquez, Jason Woodbury, Savanna Randi, Martina Pedersen, Maeve Nave, Scott La, Natalie Gallagher, Molly M. McCabe, Namrita Dhillon, Isabel Bjork, Michael Luttrell, Frank Dang, John B. MacMillan, Ralph Green, Elizabeth MillerAuston M. Kilpatrick, Olena Vaske, Michael D. Stone, Jeremy R. Sanford

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Abstract

The systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of infectious disease on college campuses. Faced with a paucity of testing in the beginning of the COVID-19 pandemic, many universities developed molecular diagnostic laboratories focused on SARS-CoV-2 diagnostic testing on campus and in their broader communities. We established the UC Santa Cruz Molecular Diagnostic Lab in early April 2020 and began testing clinical samples just five weeks later. Using a clinically-validated laboratory developed test (LDT) that avoided supply chain constraints, an automated sample pooling and processing workflow, and a custom laboratory information management system (LIMS), we expanded testing from a handful of clinical samples per day to thousands per day with the testing capacity to screen our entire campus population twice per week. In this report we describe the technical, logistical, and regulatory processes that enabled our pop-up lab to scale testing and reporting capacity to thousands of tests per day.

Original language	English (US)
Article number	e0261230
Journal	PloS one
Volume	16
Issue number	12 December
DOIs	https://doi.org/10.1371/journal.pone.0261230
State	Published - Dec 2021
Externally published	Yes

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Chang, T., Draper, J. M., van den Bout, A., Kephart, E., Maul-Newby, H., Vasquez, Y., Woodbury, J., Randi, S., Pedersen, M., Nave, M., La, S., Gallagher, N., McCabe, M. M., Dhillon, N., Bjork, I., Luttrell, M., Dang, F., MacMillan, J. B., Green, R., ... Sanford, J. R. (2021). A method for campus-wide SARS-CoV-2 surveillance at a large public university. PloS one, 16(12 December), Article e0261230. https://doi.org/10.1371/journal.pone.0261230

Chang, T, Draper, JM, van den Bout, A, Kephart, E, Maul-Newby, H, Vasquez, Y, Woodbury, J, Randi, S, Pedersen, M, Nave, M, La, S, Gallagher, N, McCabe, MM, Dhillon, N, Bjork, I, Luttrell, M, Dang, F, MacMillan, JB, Green, R, Miller, E, Kilpatrick, AM, Vaske, O, Stone, MD & Sanford, JR 2021, 'A method for campus-wide SARS-CoV-2 surveillance at a large public university', PloS one, vol. 16, no. 12 December, e0261230. https://doi.org/10.1371/journal.pone.0261230

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A method for campus-wide SARS-CoV-2 surveillance at a large public university

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