A microRNA component of the p53 tumour suppressor network

Lin He, Xingyue He, Lee P. Lim, Elisa De Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary, Gregory J. Hannon

Research output: Contribution to journalArticle

2003 Citations (Scopus)

Abstract

A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.

Original languageEnglish (US)
Pages (from-to)1130-1134
Number of pages5
JournalNature
Volume447
Issue number7148
DOIs
StatePublished - Jun 28 2007
Externally publishedYes

Fingerprint

MicroRNAs
Neoplasms
cdc Genes
Cell Cycle Checkpoints
Tumor Cell Line
Transcriptional Activation
DNA Damage
Down-Regulation
Cell Proliferation
RNA
Genes

ASJC Scopus subject areas

  • General

Cite this

He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., ... Hannon, G. J. (2007). A microRNA component of the p53 tumour suppressor network. Nature, 447(7148), 1130-1134. https://doi.org/10.1038/nature05939

A microRNA component of the p53 tumour suppressor network. / He, Lin; He, Xingyue; Lim, Lee P.; De Stanchina, Elisa; Xuan, Zhenyu; Liang, Yu; Xue, Wen; Zender, Lars; Magnus, Jill; Ridzon, Dana; Jackson, Aimee L.; Linsley, Peter S.; Chen, Caifu; Lowe, Scott W.; Cleary, Michele A.; Hannon, Gregory J.

In: Nature, Vol. 447, No. 7148, 28.06.2007, p. 1130-1134.

Research output: Contribution to journalArticle

He, L, He, X, Lim, LP, De Stanchina, E, Xuan, Z, Liang, Y, Xue, W, Zender, L, Magnus, J, Ridzon, D, Jackson, AL, Linsley, PS, Chen, C, Lowe, SW, Cleary, MA & Hannon, GJ 2007, 'A microRNA component of the p53 tumour suppressor network', Nature, vol. 447, no. 7148, pp. 1130-1134. https://doi.org/10.1038/nature05939
He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y et al. A microRNA component of the p53 tumour suppressor network. Nature. 2007 Jun 28;447(7148):1130-1134. https://doi.org/10.1038/nature05939
He, Lin ; He, Xingyue ; Lim, Lee P. ; De Stanchina, Elisa ; Xuan, Zhenyu ; Liang, Yu ; Xue, Wen ; Zender, Lars ; Magnus, Jill ; Ridzon, Dana ; Jackson, Aimee L. ; Linsley, Peter S. ; Chen, Caifu ; Lowe, Scott W. ; Cleary, Michele A. ; Hannon, Gregory J. / A microRNA component of the p53 tumour suppressor network. In: Nature. 2007 ; Vol. 447, No. 7148. pp. 1130-1134.
@article{662587d39b274900ba570545b514c00f,
title = "A microRNA component of the p53 tumour suppressor network",
abstract = "A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.",
author = "Lin He and Xingyue He and Lim, {Lee P.} and {De Stanchina}, Elisa and Zhenyu Xuan and Yu Liang and Wen Xue and Lars Zender and Jill Magnus and Dana Ridzon and Jackson, {Aimee L.} and Linsley, {Peter S.} and Caifu Chen and Lowe, {Scott W.} and Cleary, {Michele A.} and Hannon, {Gregory J.}",
year = "2007",
month = "6",
day = "28",
doi = "10.1038/nature05939",
language = "English (US)",
volume = "447",
pages = "1130--1134",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7148",

}

TY - JOUR

T1 - A microRNA component of the p53 tumour suppressor network

AU - He, Lin

AU - He, Xingyue

AU - Lim, Lee P.

AU - De Stanchina, Elisa

AU - Xuan, Zhenyu

AU - Liang, Yu

AU - Xue, Wen

AU - Zender, Lars

AU - Magnus, Jill

AU - Ridzon, Dana

AU - Jackson, Aimee L.

AU - Linsley, Peter S.

AU - Chen, Caifu

AU - Lowe, Scott W.

AU - Cleary, Michele A.

AU - Hannon, Gregory J.

PY - 2007/6/28

Y1 - 2007/6/28

N2 - A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.

AB - A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.

UR - http://www.scopus.com/inward/record.url?scp=34250851115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250851115&partnerID=8YFLogxK

U2 - 10.1038/nature05939

DO - 10.1038/nature05939

M3 - Article

C2 - 17554337

AN - SCOPUS:34250851115

VL - 447

SP - 1130

EP - 1134

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7148

ER -