The need for in vivo wireless acquisition of biological signals is emerging in various medical fields. Electrophysiological applications including recording myoelectric signals in-vivo gastric electrical activity (GEA) to study gastric dysmotility, electrocorticography (ECoG) to study pain, and transcranical motor evoked potentials (TcMEP) for intraoperative neurophysiological monitoring of spinal cord integrity require physically miniaturized devices with low power consumption and capability of implantation. These systems should provide reliable communication in real time with sufficient data rates. We have developed three telemetric systems for GEA, ECoG and TcMEP applications based on a common transceiver platform but with different design considerations. Each has been successfully validated in appropriate animal models, to demonstrate the feasibility of wireless acquisition of key electrophysiological signals.