A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation

Matthew J. Krasin, Xiaoping Xiong, Wilburn E. Reddick, Robert J. Ogg, Fredric A. Hoffer, Beth McCarville, Sue C. Kaste, Sheri L. Spunt, Fariba Navid, Andrew M. Davidoff, Lingqing Zhang, Larry E. Kun, Thomas E. Merchant

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose/Objective: This study aimed to develop objective models of radiation effects on musculature in children with soft tissue sarcoma using treatment dosimetry and clinical and quantitative magnetic resonance imaging (MRI) parameters that may be used to guide treatment planning or predict side effects. Methods: In the initial 13 patients undergoing external beam radiation therapy (RT) on a Phase II study of conformal or intensity-modulated RT for the treatment of soft tissue sarcoma approved by an Institutional Review Board, we evaluated quantitative MRI changes in the musculature to assess radiation-related treatment effects. Patients with soft tissue sarcoma, including Ewing's sarcoma, had quantitative T1, T2 and dynamic enhanced MRI (DEMRI) performed before, during (Week 4) and after RT (Week 12). Regions of interest were selected in consistent locations within and outside the high-dose regions (on ipsilateral and contralateral sides when available). Mean RT dose, T1, T2 and DEMRI parameters were calculated and modeled using a mixed random coefficient dose model. Results: The mean doses to the high- and low-dose regions were 56.4 Gy (41.8-75.3 Gy) and 13.0 Gy (0.1-37.5 Gy), respectively. Compared with tissues distant from the tumor bed, maximal enhancement was significantly increased in tissues adjacent to the tumor/tumor bed prior to RT (60.6 vs. 44.2, P=.045) and remained elevated after 12 weeks. T1 was significantly elevated in tissues adjacent to the tumor bed prior to RT (942.4 vs. 759.0, P=.0078). The slope of longitudinal change in T1 was greater for tissues that received low-dose irradiation than those that received high-dose irradiation (P=.0488). The effect of dose on the slope of T2 was different (P=.0333) when younger and older patients are compared. Conclusions: Acute affects of irradiation in muscle are quantifiable via MRI. These models provide evidence that quantifiable MRI parameters may be correlated with patient parameters of radiation dose and clinical factors including patient age. Long-term follow-up will be required to determine if acute changes correlate with clinically significant late effects.

Original languageEnglish (US)
Pages (from-to)1319-1324
Number of pages6
JournalMagnetic Resonance Imaging
Volume24
Issue number10
DOIs
StatePublished - Dec 1 2006

Fingerprint

Magnetic resonance
muscles
Radiotherapy
magnetic resonance
Muscle
Magnetic Resonance Spectroscopy
Dosimetry
Irradiation
Tissue
Muscles
dosage
Magnetic Resonance Imaging
irradiation
radiation therapy
Tumors
Sarcoma
Imaging techniques
tumors
cancer
Neoplasms

Keywords

  • Magnetic resonance imaging
  • Muscle
  • Radiation

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Krasin, M. J., Xiong, X., Reddick, W. E., Ogg, R. J., Hoffer, F. A., McCarville, B., ... Merchant, T. E. (2006). A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation. Magnetic Resonance Imaging, 24(10), 1319-1324. https://doi.org/10.1016/j.mri.2006.08.004

A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation. / Krasin, Matthew J.; Xiong, Xiaoping; Reddick, Wilburn E.; Ogg, Robert J.; Hoffer, Fredric A.; McCarville, Beth; Kaste, Sue C.; Spunt, Sheri L.; Navid, Fariba; Davidoff, Andrew M.; Zhang, Lingqing; Kun, Larry E.; Merchant, Thomas E.

In: Magnetic Resonance Imaging, Vol. 24, No. 10, 01.12.2006, p. 1319-1324.

Research output: Contribution to journalArticle

Krasin, MJ, Xiong, X, Reddick, WE, Ogg, RJ, Hoffer, FA, McCarville, B, Kaste, SC, Spunt, SL, Navid, F, Davidoff, AM, Zhang, L, Kun, LE & Merchant, TE 2006, 'A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation', Magnetic Resonance Imaging, vol. 24, no. 10, pp. 1319-1324. https://doi.org/10.1016/j.mri.2006.08.004
Krasin, Matthew J. ; Xiong, Xiaoping ; Reddick, Wilburn E. ; Ogg, Robert J. ; Hoffer, Fredric A. ; McCarville, Beth ; Kaste, Sue C. ; Spunt, Sheri L. ; Navid, Fariba ; Davidoff, Andrew M. ; Zhang, Lingqing ; Kun, Larry E. ; Merchant, Thomas E. / A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation. In: Magnetic Resonance Imaging. 2006 ; Vol. 24, No. 10. pp. 1319-1324.
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abstract = "Purpose/Objective: This study aimed to develop objective models of radiation effects on musculature in children with soft tissue sarcoma using treatment dosimetry and clinical and quantitative magnetic resonance imaging (MRI) parameters that may be used to guide treatment planning or predict side effects. Methods: In the initial 13 patients undergoing external beam radiation therapy (RT) on a Phase II study of conformal or intensity-modulated RT for the treatment of soft tissue sarcoma approved by an Institutional Review Board, we evaluated quantitative MRI changes in the musculature to assess radiation-related treatment effects. Patients with soft tissue sarcoma, including Ewing's sarcoma, had quantitative T1, T2 and dynamic enhanced MRI (DEMRI) performed before, during (Week 4) and after RT (Week 12). Regions of interest were selected in consistent locations within and outside the high-dose regions (on ipsilateral and contralateral sides when available). Mean RT dose, T1, T2 and DEMRI parameters were calculated and modeled using a mixed random coefficient dose model. Results: The mean doses to the high- and low-dose regions were 56.4 Gy (41.8-75.3 Gy) and 13.0 Gy (0.1-37.5 Gy), respectively. Compared with tissues distant from the tumor bed, maximal enhancement was significantly increased in tissues adjacent to the tumor/tumor bed prior to RT (60.6 vs. 44.2, P=.045) and remained elevated after 12 weeks. T1 was significantly elevated in tissues adjacent to the tumor bed prior to RT (942.4 vs. 759.0, P=.0078). The slope of longitudinal change in T1 was greater for tissues that received low-dose irradiation than those that received high-dose irradiation (P=.0488). The effect of dose on the slope of T2 was different (P=.0333) when younger and older patients are compared. Conclusions: Acute affects of irradiation in muscle are quantifiable via MRI. These models provide evidence that quantifiable MRI parameters may be correlated with patient parameters of radiation dose and clinical factors including patient age. Long-term follow-up will be required to determine if acute changes correlate with clinically significant late effects.",
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T1 - A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation

AU - Krasin, Matthew J.

AU - Xiong, Xiaoping

AU - Reddick, Wilburn E.

AU - Ogg, Robert J.

AU - Hoffer, Fredric A.

AU - McCarville, Beth

AU - Kaste, Sue C.

AU - Spunt, Sheri L.

AU - Navid, Fariba

AU - Davidoff, Andrew M.

AU - Zhang, Lingqing

AU - Kun, Larry E.

AU - Merchant, Thomas E.

PY - 2006/12/1

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N2 - Purpose/Objective: This study aimed to develop objective models of radiation effects on musculature in children with soft tissue sarcoma using treatment dosimetry and clinical and quantitative magnetic resonance imaging (MRI) parameters that may be used to guide treatment planning or predict side effects. Methods: In the initial 13 patients undergoing external beam radiation therapy (RT) on a Phase II study of conformal or intensity-modulated RT for the treatment of soft tissue sarcoma approved by an Institutional Review Board, we evaluated quantitative MRI changes in the musculature to assess radiation-related treatment effects. Patients with soft tissue sarcoma, including Ewing's sarcoma, had quantitative T1, T2 and dynamic enhanced MRI (DEMRI) performed before, during (Week 4) and after RT (Week 12). Regions of interest were selected in consistent locations within and outside the high-dose regions (on ipsilateral and contralateral sides when available). Mean RT dose, T1, T2 and DEMRI parameters were calculated and modeled using a mixed random coefficient dose model. Results: The mean doses to the high- and low-dose regions were 56.4 Gy (41.8-75.3 Gy) and 13.0 Gy (0.1-37.5 Gy), respectively. Compared with tissues distant from the tumor bed, maximal enhancement was significantly increased in tissues adjacent to the tumor/tumor bed prior to RT (60.6 vs. 44.2, P=.045) and remained elevated after 12 weeks. T1 was significantly elevated in tissues adjacent to the tumor bed prior to RT (942.4 vs. 759.0, P=.0078). The slope of longitudinal change in T1 was greater for tissues that received low-dose irradiation than those that received high-dose irradiation (P=.0488). The effect of dose on the slope of T2 was different (P=.0333) when younger and older patients are compared. Conclusions: Acute affects of irradiation in muscle are quantifiable via MRI. These models provide evidence that quantifiable MRI parameters may be correlated with patient parameters of radiation dose and clinical factors including patient age. Long-term follow-up will be required to determine if acute changes correlate with clinically significant late effects.

AB - Purpose/Objective: This study aimed to develop objective models of radiation effects on musculature in children with soft tissue sarcoma using treatment dosimetry and clinical and quantitative magnetic resonance imaging (MRI) parameters that may be used to guide treatment planning or predict side effects. Methods: In the initial 13 patients undergoing external beam radiation therapy (RT) on a Phase II study of conformal or intensity-modulated RT for the treatment of soft tissue sarcoma approved by an Institutional Review Board, we evaluated quantitative MRI changes in the musculature to assess radiation-related treatment effects. Patients with soft tissue sarcoma, including Ewing's sarcoma, had quantitative T1, T2 and dynamic enhanced MRI (DEMRI) performed before, during (Week 4) and after RT (Week 12). Regions of interest were selected in consistent locations within and outside the high-dose regions (on ipsilateral and contralateral sides when available). Mean RT dose, T1, T2 and DEMRI parameters were calculated and modeled using a mixed random coefficient dose model. Results: The mean doses to the high- and low-dose regions were 56.4 Gy (41.8-75.3 Gy) and 13.0 Gy (0.1-37.5 Gy), respectively. Compared with tissues distant from the tumor bed, maximal enhancement was significantly increased in tissues adjacent to the tumor/tumor bed prior to RT (60.6 vs. 44.2, P=.045) and remained elevated after 12 weeks. T1 was significantly elevated in tissues adjacent to the tumor bed prior to RT (942.4 vs. 759.0, P=.0078). The slope of longitudinal change in T1 was greater for tissues that received low-dose irradiation than those that received high-dose irradiation (P=.0488). The effect of dose on the slope of T2 was different (P=.0333) when younger and older patients are compared. Conclusions: Acute affects of irradiation in muscle are quantifiable via MRI. These models provide evidence that quantifiable MRI parameters may be correlated with patient parameters of radiation dose and clinical factors including patient age. Long-term follow-up will be required to determine if acute changes correlate with clinically significant late effects.

KW - Magnetic resonance imaging

KW - Muscle

KW - Radiation

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