A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We measured the changes of oxy-hemoglobin (Δ[HbO 2]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO 2). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO 2], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO 2. This preliminary study has demonstrated that MRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages301-307
Number of pages7
Volume5693
DOIs
StatePublished - 2005
EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Other

OtherOptical Tomography and Spectroscopy of Tissue VI
CountryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Keywords

  • Hyperoxic gas
  • Model
  • Oxygenation
  • Tumor

ASJC Scopus subject areas

  • Engineering(all)

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