A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We measured the changes of oxy-hemoglobin (Δ[HbO 2]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO 2). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO 2], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO 2. This preliminary study has demonstrated that MRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages301-307
Number of pages7
Volume5693
DOIs
StatePublished - 2005
EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Other

OtherOptical Tomography and Spectroscopy of Tissue VI
CountryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Fingerprint

Hemodynamics
Rats
Tumors
Gases
Hemoglobin
Blood
Near infrared spectroscopy
Oxygen
Mathematical models
Oxygenation

Keywords

  • Hyperoxic gas
  • Model
  • Oxygenation
  • Tumor

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Xia, M., Mason, R. P., & Liu, H. (2005). A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5693, pp. 301-307). [61] https://doi.org/10.1117/12.592291

A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. / Xia, Mengna; Mason, Ralph P.; Liu, Hanli.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 5693 2005. p. 301-307 61.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xia, M, Mason, RP & Liu, H 2005, A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5693, 61, pp. 301-307, Optical Tomography and Spectroscopy of Tissue VI, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.592291
Xia M, Mason RP, Liu H. A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraca EM, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5693. 2005. p. 301-307. 61 https://doi.org/10.1117/12.592291
Xia, Mengna ; Mason, Ralph P. ; Liu, Hanli. / A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / B. Chance ; R.R. Alfano ; B.J. Tromberg ; M. Tamura ; E.M. Sevick-Muraca. Vol. 5693 2005. pp. 301-307
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