A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate

Baowei Fei, David M. Schuster, Viraj Master, Hamed Akbari, Aaron Fenster, Peter Nieh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

Abstract

Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. However, this biopsy approach uses two-dimensional (2D) ultrasound images to guide biopsy and can miss up to 30% of prostate cancers. We are developing a molecular image-directed, three-dimensional (3D) ultrasound imageguided biopsy system for improved detection of prostate cancer. The system consists of a 3D mechanical localization system and software workstation for image segmentation, registration, and biopsy planning. In order to plan biopsy in a 3D prostate, we developed an automatic segmentation method based wavelet transform. In order to incorporate PET/CT images into ultrasound-guided biopsy, we developed image registration methods to fuse TRUS and PET/CT images. The segmentation method was tested in ten patients with a DICE overlap ratio of 92.4% ± 1.1 %. The registration method has been tested in phantoms. The biopsy system was tested in prostate phantoms and 3D ultrasound images were acquired from two human patients. We are integrating the system for PET/CT directed, 3D ultrasound-guided, targeted biopsy in human patients.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
DOIs
StatePublished - May 1 2012
Externally publishedYes
EventMedical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8316
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

Fingerprint

Biopsy
Prostate
Ultrasonics
cancer
Prostatic Neoplasms
Image-Guided Biopsy
fuses
workstations
Wavelet Analysis
Three-Dimensional Imaging
wavelet analysis
planning
Image registration
Electric fuses
Image segmentation
Wavelet transforms
Software
computer programs
Planning

Keywords

  • 3D ultrasound
  • image segmentation
  • Molecular imaging
  • nonrigid registration
  • PET/CT
  • prostate biopsy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Fei, B., Schuster, D. M., Master, V., Akbari, H., Fenster, A., & Nieh, P. (2012). A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate. In Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling [831613] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8316). https://doi.org/10.1117/12.912182

A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate. / Fei, Baowei; Schuster, David M.; Master, Viraj; Akbari, Hamed; Fenster, Aaron; Nieh, Peter.

Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling. 2012. 831613 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8316).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fei, B, Schuster, DM, Master, V, Akbari, H, Fenster, A & Nieh, P 2012, A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate. in Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling., 831613, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8316, Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, CA, United States, 2/5/12. https://doi.org/10.1117/12.912182
Fei B, Schuster DM, Master V, Akbari H, Fenster A, Nieh P. A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate. In Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling. 2012. 831613. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.912182
Fei, Baowei ; Schuster, David M. ; Master, Viraj ; Akbari, Hamed ; Fenster, Aaron ; Nieh, Peter. / A molecular image-directed, 3D ultrasound-guided biopsy system for the prostate. Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling. 2012. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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