A molecular revolution in uveal melanoma: Implications for patient care and targeted therapy

J. William Harbour; Daniel L. Chao

doi:10.1016/j.ophtha.2013.12.014

A molecular revolution in uveal melanoma: Implications for patient care and targeted therapy

J. William Harbour, Daniel L. Chao

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Uveal melanoma is the most common primary intraocular malignancy and has a strong propensity for fatal metastasis. Recent advances in the molecular genetics of uveal melanoma are revolutionizing our understanding of this cancer and the care of patients. The development of a new molecular classification of uveal melanoma based on a widely available 15-gene expression profile now allows patients at high risk of metastasis to be identified early so that individualized management can be offered. The recent discovery of major driver mutations in uveal melanoma provide a rational basis for development of new targeted therapies. Taken together, these advances are transforming our understanding and management of uveal melanoma with the ultimate goal of improving patient outcomes.

Original language	English (US)
Pages (from-to)	1281-1288
Number of pages	8
Journal	Ophthalmology
Volume	121
Issue number	6
DOIs	https://doi.org/10.1016/j.ophtha.2013.12.014
State	Published - Jun 2014
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.ophtha.2013.12.014

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@article{01ef8379c52445169c7050939d573c22,

title = "A molecular revolution in uveal melanoma: Implications for patient care and targeted therapy",

abstract = "Uveal melanoma is the most common primary intraocular malignancy and has a strong propensity for fatal metastasis. Recent advances in the molecular genetics of uveal melanoma are revolutionizing our understanding of this cancer and the care of patients. The development of a new molecular classification of uveal melanoma based on a widely available 15-gene expression profile now allows patients at high risk of metastasis to be identified early so that individualized management can be offered. The recent discovery of major driver mutations in uveal melanoma provide a rational basis for development of new targeted therapies. Taken together, these advances are transforming our understanding and management of uveal melanoma with the ultimate goal of improving patient outcomes.",

author = "{William Harbour}, J. and Chao, {Daniel L.}",

note = "Funding Information: Supported by the National Cancer Institute (grant no.: R01 CA125970 [J.W.H.]), National Institutes of Health (grant no.: P30EY014801 ), Bethesda, Maryland; the Melanoma Research Alliance ; the Melanoma Research Foundation ; the Tumori Foundation ; and Unrestricted Grant from Research to Prevent Blindness, Inc , New York, New York; and the United States Department of Defense , Washington, DC (grant no.: W81XWH-09-1-0675 [Bascom Palmer Eye Institute]). The funding organizations had no role in the design or conduct of this research. ",

year = "2014",

month = jun,

doi = "10.1016/j.ophtha.2013.12.014",

language = "English (US)",

volume = "121",

pages = "1281--1288",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "6",

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T1 - A molecular revolution in uveal melanoma

T2 - Implications for patient care and targeted therapy

AU - William Harbour, J.

AU - Chao, Daniel L.

N1 - Funding Information: Supported by the National Cancer Institute (grant no.: R01 CA125970 [J.W.H.]), National Institutes of Health (grant no.: P30EY014801 ), Bethesda, Maryland; the Melanoma Research Alliance ; the Melanoma Research Foundation ; the Tumori Foundation ; and Unrestricted Grant from Research to Prevent Blindness, Inc , New York, New York; and the United States Department of Defense , Washington, DC (grant no.: W81XWH-09-1-0675 [Bascom Palmer Eye Institute]). The funding organizations had no role in the design or conduct of this research.

PY - 2014/6

Y1 - 2014/6

N2 - Uveal melanoma is the most common primary intraocular malignancy and has a strong propensity for fatal metastasis. Recent advances in the molecular genetics of uveal melanoma are revolutionizing our understanding of this cancer and the care of patients. The development of a new molecular classification of uveal melanoma based on a widely available 15-gene expression profile now allows patients at high risk of metastasis to be identified early so that individualized management can be offered. The recent discovery of major driver mutations in uveal melanoma provide a rational basis for development of new targeted therapies. Taken together, these advances are transforming our understanding and management of uveal melanoma with the ultimate goal of improving patient outcomes.

AB - Uveal melanoma is the most common primary intraocular malignancy and has a strong propensity for fatal metastasis. Recent advances in the molecular genetics of uveal melanoma are revolutionizing our understanding of this cancer and the care of patients. The development of a new molecular classification of uveal melanoma based on a widely available 15-gene expression profile now allows patients at high risk of metastasis to be identified early so that individualized management can be offered. The recent discovery of major driver mutations in uveal melanoma provide a rational basis for development of new targeted therapies. Taken together, these advances are transforming our understanding and management of uveal melanoma with the ultimate goal of improving patient outcomes.

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A molecular revolution in uveal melanoma: Implications for patient care and targeted therapy

Abstract

ASJC Scopus subject areas

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