TY - JOUR
T1 - A moment-based approach for DVH-guided radiotherapy treatment plan optimization
AU - Zarepisheh, M.
AU - Shakourifar, M.
AU - Trigila, G.
AU - Ghomi, P. S.
AU - Couzens, S.
AU - Abebe, A.
AU - Noreña, L.
AU - Shang, W.
AU - Jiang, Steve B.
AU - Zinchenko, Y.
PY - 2013/3/21
Y1 - 2013/3/21
N2 - The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.
AB - The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.
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U2 - 10.1088/0031-9155/58/6/1869
DO - 10.1088/0031-9155/58/6/1869
M3 - Article
C2 - 23442553
AN - SCOPUS:84874865982
SN - 0031-9155
VL - 58
SP - 1869
EP - 1887
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 6
ER -