A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

L. Orci; F. Malaisse-Lagae; M. Ravazzola; D. Rouiller; A. E. Renold; A. Perrelet; Roger H Unger

doi:10.1172/JCI108154

A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

L. Orci, F. Malaisse-Lagae, M. Ravazzola, D. Rouiller, A. E. Renold, A. Perrelet, Roger H Unger

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Abstract

By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

Original language	English (US)
Pages (from-to)	1066-1070
Number of pages	5
Journal	Unknown Journal
Volume	56
Issue number	4
DOIs	https://doi.org/10.1172/JCI108154
State	Published - 1975

ASJC Scopus subject areas

General Medicine

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10.1172/JCI108154

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AU - Orci, L.

AU - Malaisse-Lagae, F.

AU - Ravazzola, M.

AU - Rouiller, D.

AU - Renold, A. E.

AU - Perrelet, A.

AU - Unger, Roger H

PY - 1975

Y1 - 1975

N2 - By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

AB - By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

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JF - Unknown Journal

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A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

Abstract

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