A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

L. Orci, F. Malaisse-Lagae, M. Ravazzola, D. Rouiller, A. E. Renold, A. Perrelet, Roger H Unger

Research output: Contribution to journalArticle

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Abstract

By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalJournal of Clinical Investigation
Volume56
Issue number4
StatePublished - 1975

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Islets of Langerhans
Cell Communication
Gap Junctions
Tight Junctions
Homeostasis
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orci, L., Malaisse-Lagae, F., Ravazzola, M., Rouiller, D., Renold, A. E., Perrelet, A., & Unger, R. H. (1975). A morphological basis for intercellular communication between α and β cells in the endocrine pancreas. Journal of Clinical Investigation, 56(4), 1066-1070.

A morphological basis for intercellular communication between α and β cells in the endocrine pancreas. / Orci, L.; Malaisse-Lagae, F.; Ravazzola, M.; Rouiller, D.; Renold, A. E.; Perrelet, A.; Unger, Roger H.

In: Journal of Clinical Investigation, Vol. 56, No. 4, 1975, p. 1066-1070.

Research output: Contribution to journalArticle

Orci, L, Malaisse-Lagae, F, Ravazzola, M, Rouiller, D, Renold, AE, Perrelet, A & Unger, RH 1975, 'A morphological basis for intercellular communication between α and β cells in the endocrine pancreas', Journal of Clinical Investigation, vol. 56, no. 4, pp. 1066-1070.
Orci L, Malaisse-Lagae F, Ravazzola M, Rouiller D, Renold AE, Perrelet A et al. A morphological basis for intercellular communication between α and β cells in the endocrine pancreas. Journal of Clinical Investigation. 1975;56(4):1066-1070.
Orci, L. ; Malaisse-Lagae, F. ; Ravazzola, M. ; Rouiller, D. ; Renold, A. E. ; Perrelet, A. ; Unger, Roger H. / A morphological basis for intercellular communication between α and β cells in the endocrine pancreas. In: Journal of Clinical Investigation. 1975 ; Vol. 56, No. 4. pp. 1066-1070.
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