A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

L. Orci, F. Malaisse-Lagae, M. Ravazzola, D. Rouiller, A. E. Renold, A. Perrelet, Roger H Unger

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalUnknown Journal
Volume56
Issue number4
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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