A morphological basis for intercellular communication between α and β cells in the endocrine pancreas

L. Orci, F. Malaisse-Lagae, M. Ravazzola, D. Rouiller, A. E. Renold, A. Perrelet, Roger H Unger

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Abstract

By degranulating β cells in the islets of Langerhans of the rat with sulfonylurea, it was possible to distinguish unambiguously α cells from β cells in freeze fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between α and β cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of α and β cells maintaining glucose homeostasis within tightly constricted limits.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalUnknown Journal
Volume56
Issue number4
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Medicine(all)

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    Orci, L., Malaisse-Lagae, F., Ravazzola, M., Rouiller, D., Renold, A. E., Perrelet, A., & Unger, R. H. (1975). A morphological basis for intercellular communication between α and β cells in the endocrine pancreas. Unknown Journal, 56(4), 1066-1070. https://doi.org/10.1172/JCI108154