A multi-scale elasto-plastic model of articular cartilage

Malek Adouni, Yasin Y. Dhaher

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Collagen damage is one of the earliest signs of cartilage degeneration and the onset of osteoarthritis (OA), but the connection between the microscale damage and macroscale tissue function is unclear. We argue that a multiscale model can help elucidate the biochemical and mechanical underpinnings of OA by connecting the microscale defects in collagen fibrils to the macroscopic cartilage mechanics. We investigated this connection using a multiscale fibril reinforced hyperelastoplastic (MFRHEP) model that accounts for the structural architecture of the soft tissue, starting from tropocollagen molecules that form fibrils, and moving to the complete soft tissue. This model was driven by reported experimental data from unconfined compression testing of cartilage. The model successfully described the observed transient response of the articular cartilage in unconfined and indentation tests with low and high loading rates. We used this model to understand damage initiation and propagation as a function of the cross-link density between tropocollagen molecules. This approach appeared to provide a realistic simulation of damage when compared with certain published studies. The current construct presents the first attempt to express the aggregate cartilage damage in terms of the cross-link density at the microfibril level.

Original languageEnglish (US)
Pages (from-to)2891-2898
Number of pages8
JournalJournal of Biomechanics
Volume49
Issue number13
DOIs
StatePublished - Sep 6 2016
Externally publishedYes

Fingerprint

Cartilage
Articular Cartilage
Plastics
Tropocollagen
Osteoarthritis
Tissue
Collagen
Data Compression
Microfibrils
Structural Models
Compression testing
Mechanics
Molecules
Indentation
Transient analysis
Defects

Keywords

  • Cartialge damage
  • Fibrils
  • Multiscale model
  • Osteoarthritis
  • Tropocollagen

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

A multi-scale elasto-plastic model of articular cartilage. / Adouni, Malek; Dhaher, Yasin Y.

In: Journal of Biomechanics, Vol. 49, No. 13, 06.09.2016, p. 2891-2898.

Research output: Contribution to journalArticle

@article{c85e6afe05534926bf8c1c1bae08a3bf,
title = "A multi-scale elasto-plastic model of articular cartilage",
abstract = "Collagen damage is one of the earliest signs of cartilage degeneration and the onset of osteoarthritis (OA), but the connection between the microscale damage and macroscale tissue function is unclear. We argue that a multiscale model can help elucidate the biochemical and mechanical underpinnings of OA by connecting the microscale defects in collagen fibrils to the macroscopic cartilage mechanics. We investigated this connection using a multiscale fibril reinforced hyperelastoplastic (MFRHEP) model that accounts for the structural architecture of the soft tissue, starting from tropocollagen molecules that form fibrils, and moving to the complete soft tissue. This model was driven by reported experimental data from unconfined compression testing of cartilage. The model successfully described the observed transient response of the articular cartilage in unconfined and indentation tests with low and high loading rates. We used this model to understand damage initiation and propagation as a function of the cross-link density between tropocollagen molecules. This approach appeared to provide a realistic simulation of damage when compared with certain published studies. The current construct presents the first attempt to express the aggregate cartilage damage in terms of the cross-link density at the microfibril level.",
keywords = "Cartialge damage, Fibrils, Multiscale model, Osteoarthritis, Tropocollagen",
author = "Malek Adouni and Dhaher, {Yasin Y.}",
year = "2016",
month = "9",
day = "6",
doi = "10.1016/j.jbiomech.2016.06.031",
language = "English (US)",
volume = "49",
pages = "2891--2898",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "13",

}

TY - JOUR

T1 - A multi-scale elasto-plastic model of articular cartilage

AU - Adouni, Malek

AU - Dhaher, Yasin Y.

PY - 2016/9/6

Y1 - 2016/9/6

N2 - Collagen damage is one of the earliest signs of cartilage degeneration and the onset of osteoarthritis (OA), but the connection between the microscale damage and macroscale tissue function is unclear. We argue that a multiscale model can help elucidate the biochemical and mechanical underpinnings of OA by connecting the microscale defects in collagen fibrils to the macroscopic cartilage mechanics. We investigated this connection using a multiscale fibril reinforced hyperelastoplastic (MFRHEP) model that accounts for the structural architecture of the soft tissue, starting from tropocollagen molecules that form fibrils, and moving to the complete soft tissue. This model was driven by reported experimental data from unconfined compression testing of cartilage. The model successfully described the observed transient response of the articular cartilage in unconfined and indentation tests with low and high loading rates. We used this model to understand damage initiation and propagation as a function of the cross-link density between tropocollagen molecules. This approach appeared to provide a realistic simulation of damage when compared with certain published studies. The current construct presents the first attempt to express the aggregate cartilage damage in terms of the cross-link density at the microfibril level.

AB - Collagen damage is one of the earliest signs of cartilage degeneration and the onset of osteoarthritis (OA), but the connection between the microscale damage and macroscale tissue function is unclear. We argue that a multiscale model can help elucidate the biochemical and mechanical underpinnings of OA by connecting the microscale defects in collagen fibrils to the macroscopic cartilage mechanics. We investigated this connection using a multiscale fibril reinforced hyperelastoplastic (MFRHEP) model that accounts for the structural architecture of the soft tissue, starting from tropocollagen molecules that form fibrils, and moving to the complete soft tissue. This model was driven by reported experimental data from unconfined compression testing of cartilage. The model successfully described the observed transient response of the articular cartilage in unconfined and indentation tests with low and high loading rates. We used this model to understand damage initiation and propagation as a function of the cross-link density between tropocollagen molecules. This approach appeared to provide a realistic simulation of damage when compared with certain published studies. The current construct presents the first attempt to express the aggregate cartilage damage in terms of the cross-link density at the microfibril level.

KW - Cartialge damage

KW - Fibrils

KW - Multiscale model

KW - Osteoarthritis

KW - Tropocollagen

UR - http://www.scopus.com/inward/record.url?scp=84995632314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995632314&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2016.06.031

DO - 10.1016/j.jbiomech.2016.06.031

M3 - Article

C2 - 27435568

AN - SCOPUS:84995632314

VL - 49

SP - 2891

EP - 2898

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 13

ER -