A Multicenter Controlled Study to Evaluate Multiple Treatments with Nonthermal Focused Ultrasound for Noninvasive Fat Reduction

William P. Coleman, William Coleman, Robert A. Weiss, Jeffrey M. Kenkel, Dean D. Ad-El, Ruthie Amir

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND Demand for nonsurgical esthetic body procedures has led to the development of noninvasive techniques for reducing localized subcutaneous adipose tissue. OBJECTIVE This study assessed multiple treatments with nonthermal focused ultrasound for noninvasive abdominal treatment of excess fat deposits. MATERIALS AND METHODS Subjects were randomly assigned to Group 1 for a 4-week control phase before undergoing 3 abdominal fat reduction treatments, at 2-week intervals, or to Group 2 for immediate treatment. Weight, abdominal circumference, tolerability to treatment, subject satisfaction, and adverse events were recorded. RESULTS Weight remained stable in the 126 participants. Mean reduction in midline circumference was 2.5 ± 2.1 cm in the Group 1 and 3.5 ± 2.7 cm in the Group 2 at Week 22. The effect of multiple treatments was cumulative with a steady decrease in abdominal circumferences during the study. Erythema was observed in 28% of treatments but was mild and transient in nature. Subjects tolerated the treatments well and were satisfied with treatment outcome. CONCLUSION The study demonstrated the efficacy and safety of multiple nonthermal focused ultrasound treatments of excess abdominal fat deposits. Although the remodeling effect is minor compared with traditional surgical procedures, successive focused ultrasound treatments significantly reduced treatment area circumference, while avoiding invasive techniques and their associated disadvantages.

Original languageEnglish (US)
Pages (from-to)50-57
Number of pages8
JournalDermatologic Surgery
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Abdominal Fat
Multicenter Studies
Fats
Weights and Measures
Subcutaneous Fat
Erythema
Esthetics
Safety

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

A Multicenter Controlled Study to Evaluate Multiple Treatments with Nonthermal Focused Ultrasound for Noninvasive Fat Reduction. / Coleman, William P.; Coleman, William; Weiss, Robert A.; Kenkel, Jeffrey M.; Ad-El, Dean D.; Amir, Ruthie.

In: Dermatologic Surgery, Vol. 43, No. 1, 01.01.2017, p. 50-57.

Research output: Contribution to journalArticle

Coleman, William P. ; Coleman, William ; Weiss, Robert A. ; Kenkel, Jeffrey M. ; Ad-El, Dean D. ; Amir, Ruthie. / A Multicenter Controlled Study to Evaluate Multiple Treatments with Nonthermal Focused Ultrasound for Noninvasive Fat Reduction. In: Dermatologic Surgery. 2017 ; Vol. 43, No. 1. pp. 50-57.
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